In vivo glucose utilization by individual tissues during nonlethal hypermetabolic sepsis
In vivo glucose utilization by individual tissues during nonlethal hypermetabolic sepsis
复制标题
非致死性高代谢脓毒症期间各个组织的体内葡萄糖利用
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
J. Spitzer
中科院分区：
文献类型：
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作者：
K. Mészáros;C. Lang;G. Bagby;J. Spitzer
Febrile sepsis was induced in rats by repeated s.c. injections of live Escherichia coli bacteria. Glucose utilization of different tissues was investigated in vivo by using the 2‐deoxyglucose tracer technique. In septic rats the rate of glucose utilization was increased in macrophage‐rich tissues, including the liver (2.7‐fold), spleen (2.4‐fold), and ileum (1.6‐fold), compared with tissues from time‐matched nonseptic animals. A smaller increase in glucose utilization was evident in the abdominal muscle (1.3‐fold) and in the white portion of the quadriceps muscle (1.3‐fold). Changes were not significant in nine other tissues, including the brain. We postulate that in sepsis the mononuclear phagocyte system may be responsible for most of the increment of glucose utilization, and the latter provides metabolic support for the increased antibacterial activity of these cells.—Meszaros, K.; Lang, C. H.; Bagby, G. J.; Spitzer, J. J. In vivo glucose utilization by individual tissues during nonlethal hypermetabolic sepsis. FASEB J. 2: 3083‐3086; 1988.
