Embolization with cellulose porous beads, I: An experimental study.
Embolization with cellulose porous beads, I: An experimental study.
复制标题
纤维素多孔珠栓塞，I：实验研究。
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
H. Iwata
中科院分区：
文献类型：
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作者：
J. Hamada;Yukitaka Ushio;K. Kazekawa;T. Tsukahara;Nobuo Hashimoto;H. Iwata
目的
目的探讨纤维素多孔微球（CPB）作为血管永久性栓塞材料的可行性。
方法
对12只成年杂种犬的单侧肾动脉进行体外循环栓塞。分别于栓塞后即刻、1小时、4周和12周进行选择性肾血管造影。在手术后1小时（n = 4）、4周（n = 4）或12周（n = 4）处死犬。将肾脏整块取出并进行组织学检查。
结果
CPB很容易通过微导管注射，很容易用放射密度控制，并且不粘附在导管上。栓塞后获得的肾血管造影显示肾动脉完全闭塞。在显微镜下，CPB行进至直径尺寸大致相同的血管。较大的血管被颗粒聚集物堵塞，没有留下开放空间。我们没有发现血管壁破裂，没有血管周围出血的证据，也没有血管壁或周围组织的炎性变化。
结论
CPB易于使用;它们到达远端部位并产生均匀和永久的闭塞，没有特定的炎症变化。这项实验研究的良好结果导致了CPB的临床试验。
PURPOSE
To study the possibility of using cellulose porous beads (CPBs) as a solid embolic material for the permanent occlusion of blood vessels.
METHODS
Unilateral renal arteries of 12 adult mongrel dogs were embolized with CPBs. Selective renal angiograms were obtained immediately, 1 hour, 4 weeks, and 12 weeks after the embolization. The dogs were killed 1 hour (n = 4), 4 weeks (n = 4), or 12 weeks (n = 4) after the procedure. The kidneys were removed en bloc and examined histologically.
RESULTS
The CPBs were easily injected through a microcatheter, were readily controlled with radiodensity, and did not adhere to the catheter. Renal angiograms obtained after embolization disclosed complete occlusion of the renal artery. Microscopically, the CPBs traveled to vessels with approximately the same diameter size. Larger vessels were occluded by aggregations of particles that left no open spaces. We found no disruption of the vessel wall, no evidence of perivascular hemorrhage, and no inflammatory changes of the vessel wall or the surrounding tissues.
CONCLUSION
The CPBs were easy to use; they reached distal sites and produced a homogeneous and permanent occlusion without specific inflammatory changes. The good results of this experimental study led to a clinical trial of CPBs.
DOI：
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发表时间：
2004
期刊：
J Neurosurg 101
影响因子：
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作者：
Youichi Saitoh;富永 篤;有田 和徳;Kato Amami
通讯作者：
Kato Amami