Influences of Hunger, Satiety and Oral Glucose on Functional Brain Connectivity: A Multimethod Resting-State fMRI Study
Influences of Hunger, Satiety and Oral Glucose on Functional Brain Connectivity: A Multimethod Resting-State fMRI Study
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DOI：
10.1016/j.neuroscience.2018.04.029
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发表时间：
2018-07-01
期刊：
影响因子：
3.3
通讯作者：
Muente, Thomas F.
中科院分区：
文献类型：
--
作者：
Al-Zubaidi, Arkan;Heldmann, Marcus;Muente, Thomas F.
生物体的一项主要调节任务是保持大脑功能相对恒定，尽管代谢发生变化（例如饥饿与饱腹感）或能量可用性（例如葡萄糖施用）。静息态功能磁共振成像（rs-fMRI）可以揭示大脑功能的变化，但之前的研究主要集中在下丘脑。因此，我们采用全脑方法，对 24 名健康、体重正常的男性进行了一次 36 小时禁食后和一次饱食状态（36 小时内六餐）的检查。每次治疗结束时，在口服75g葡萄糖之前和之后记录rs-fMRI。我们根据 rs-fMRI 数据计算了局部连通性（区域同质性 [ReHo]）、全局连通性（中心度 [DC]）和幅度（低频波动的分数幅度 [fALFF]）图。我们发现，葡萄糖给药选择性地减少了左侧辅助运动区的所有测量，并增加了右侧额中回和额上回的 ReHo 和 fALFF。对于 fALFF，我们观察到左侧丘脑代谢状态和葡萄糖之间存在显着的相互作用。这种相互作用是由葡萄糖治疗后饥饿状态下 fALFF 相对于饱腹状态的增加所驱动的。我们的结果表明，fALFF 分析是检测代谢状态对静息状态大脑活动影响的最敏感的方法。此外，我们表明，多方法 rs-fMRI 提供了一种公正的方法来识别与稳态和热量摄入变化相关的自发大脑活动。 (C) 2018 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
A major regulatory task of the organism is to keep brain functions relatively constant in spite of metabolic changes (e.g., hunger vs. satiety) or availability of energy (e.g., glucose administration). Resting-state functional magnetic resonance imaging (rs-fMRI) can reveal resulting changes in brain function but previous studies have focused mostly on the hypothalamus. Therefore, we took a whole-brain approach and examined 24 healthy normal-weight men once after 36 h of fasting and once in a satiated state (six meals over the course of 36 h). At the end of each treatment, rs-fMRI was recorded before and after the oral administration of 75g of glucose. We calculated local connectivity (regional homogeneity [ReHo]), global connectivity (degree of centrality [DC]), and amplitude (fractional amplitude of low-frequency fluctuation [fALFF]) maps from the rs-fMRI data. We found that glucose administration reduced all measures selectively in the left supplementary motor area and increased ReHo and fALFF in the right middle and superior frontal gyri. For fALFF, we observed a significant interaction between metabolic states and glucose in the left thalamus. This interaction was driven by a fALFF increase after glucose treatment in the hunger relative to the satiety condition. Our results indicate that fALFF analysis is the most sensitive measure to detect effects of metabolic states on resting-state brain activity. Moreover, we show that multimethod rs-fMRI provides an unbiased approach to identify spontaneous brain activity associated with changes in homeostasis and caloric intake. (C) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.