Measuring drug saturation solubility in thin polymer films: use of a thin acceptor layer.
Measuring drug saturation solubility in thin polymer films: use of a thin acceptor layer.
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测量聚合物薄膜中的药物饱和溶解度：使用薄受体层
DOI：
10.1016/j.ijpharm.2015.01.018
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发表时间：
2015
影响因子：
5.8
通讯作者：
Geoffrey Lee
中科院分区：
文献类型：
--
作者：
Anders Kunst;Geoffrey Lee
采用5层层压技术测定了东莨菪碱在两种压敏胶duro - tak中的饱和溶解度。受体层厚度小于25 μm，有利于快速分配平衡。使用DURO-TAK 87-2510, 7天后测量的饱和溶解度为5.2±0.6% w/w。DURO-TAK 87-4098的饱和溶解度稍高，7天后为7.9±0.7% w/w。这些数值在大约30天的实验时间内保持不变。在这两种情况下，受体在实验结束时都没有结晶物质。这有力地表明，在受体层的饱和溶液和仍然存在于供体层的结晶药物之间已经达到了平衡。在受体中加入轻质液体石蜡对87-4098有增溶作用，对87-2510无增溶作用。我们推荐一些实验条件，我们认为是必要的，以获得可靠和准确的结果与该技术。如果操作正确，可以得到一个可行的结果。
The saturation solubility of scopolamine base in two pressure sensitive adhesive DURO-TAKs has been determined using the 5-layer laminate technique. The acceptor layer had a thickness of less than 25 μm to promote a rapid partitioning equilibrium. With DURO-TAK 87-2510 the saturation solubility is 5.2 ± 0.6% w/w when measured after 7 days. With DURO-TAK 87-4098 the saturation solubility is slightly higher, 7.9 ± 0.7% w/w after 7 days. These values remained constant up to approximately 30 days’ experimental time. In both cases the acceptor was free of crystalline material at the end of the experiment. This strongly suggests that that equilibrium had been reached between the saturated solution in the acceptor layer and the crystalline drug still present in the donor layer. The addition of light liquid paraffin to the acceptor produced a solubilizing effect with 87-4098 but not 87-2510. We recommend some experimental conditions that we consider to be necessary to achieve a reliable and accurate result with this technique. If performed correctly, it can give a feasible result.
用于确定药物在压敏粘合剂薄膜中饱和溶解度的 5 层层压技术的数值解
影响因子：
3.4
作者：
Eberhard Bänsch;Simone Reismann;Geoffrey Lee
通讯作者：
Geoffrey Lee
测量压敏粘合膜中药物饱和溶解度的五层层压技术的评估
影响因子：
3.8
作者：
Simone Reismann;Geoffrey Lee
通讯作者：
Geoffrey Lee