Small, soft, and safe microactuator for retinal pigment epithelium transplantation
Small, soft, and safe microactuator for retinal pigment epithelium transplantation
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用于视网膜色素上皮移植的小型、柔软且安全的微执行器
DOI：
10.1109/memsys.2007.4433083
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Satoshi Konishi
中科院分区：
文献类型：
--
作者：
Yusaku Watanabe;Masanori Maeda;N. Yaji;R. Nakamura;Hiroshi Iseki;M. Yamato;T. Okano;Sadao Hori;Satoshi Konishi
本文提出一种新的视网膜色素上皮（RPE）片移植手术工具。所提出的工具采用气动气球致动器（PBA）的原则。由于PBA是由PDMS材料制成的，并由气动压力驱动，因此可以设计出体积小、柔软、安全的手术工具。PBA的这些独特的特性对于诸如在眼球中的RPE片移植这样的具有挑战性的手术是有吸引力的。考虑到RPE片的尺寸（3mm × 3mm），工具的设计头部尺寸为3mm × 3mm × 100 μ m。所开发的工具可以通过独立控制不同的PBA来执行顺序运动，从而将RPE片引入并移植到眼球中。通过移植工具的移动产生的力被测量为大约3mN，这在眼球中是允许的。使用所开发的工具进行体外和体内测试的实验结果将被报告，以证明我们的策略的可行性。
This paper proposes a novel surgical tool for the retinal pigment epithelium (RPE) sheet transplantation. The proposed tool employs the principle of pneumatic balloon actuator (PBA). It is possible to design small, soft and safe surgical tool by using PBA because PBA is made of PDMS and driven by pneumatic pressure. These distinctive characteristics of PBA are attractive for such a challenging surgery as the RPE sheet transplantation in an eyeball. The designed head size of tool is 3 mm times 3 mm times 100 mum by taking account of the size of the RPE sheet (3 mm times 3 mm). The developed tool can perform sequential motions through independent control of different PBA so as to introduce and transplant the RPE sheet to an eyeball. Generated force by the movement of the transplantation tool is measured around 3 mN, which is allowable in an eyeball. Experimental results of both in vitro and in vivo test by using the developed tool will be reported to demonstrate feasibility of our strategy.