Steroidal saponins from the leaves of Cestrum sendtenerianum
Steroidal saponins from the leaves of Cestrum sendtenerianum
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DOI：
10.1016/s0031-9422(00)00109-6
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发表时间：
2000-12-01
期刊：
影响因子：
3.8
通讯作者：
Sashida, Y
中科院分区：
文献类型：
--
作者：
Haraguchi, M;Mimaki, Y;Sashida, Y
从茄科植物仙丹（Cestrum sendtenerianum） EtOH提取物中分离得到5个甾体皂苷类化合物，通过H-1、C-13、二维核磁共振谱分析和水解解理证实了这5个甾体皂苷类化合物的活性。这些皂苷在螺甾醇骨架的C-1 β、C-2 α和C-3 β位置上含有3个羟基，并且在C-3位置上具有二甘油三酯或甘油三酯的共同结构特征。其中一种化合物螺甾醇甘油三苷对HL-60人早幼粒细胞白血病细胞具有弱的细胞毒活性，IC50值为7.7马克/毫升。(C) 2000 Elsevier Science Ltd.版权所有。
Five steroidal saponins were isolated from the EtOH extract of Cestrum sendtenerianum (Solanaceae), as confirmed by detailed analysis of their H-1, C-13, and two-dimensional NMR spectral data, and by the results of hydrolytic cleavage. The saponins were revealed to contain three hydroxyl groups at the C-1 beta, C-2 alpha, and C-3 beta positions in the spirostanol skeleton, and to bear a di- or triglycoside at C-3 as the common structural features. One of the compounds, a spirostanol triglycoside, showed weak cytotoxic activity on HL-60 human promyelocytic leukemia cells, with an IC50 value of 7.7 mug/ml. (C) 2000 Elsevier Science Ltd. All rights reserved.