Concurrent tonotopic processing streams in auditory cortex
Concurrent tonotopic processing streams in auditory cortex
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DOI：
10.1093/cercor/bhh006
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发表时间：
2004-04-01
期刊：
影响因子：
3.7
通讯作者：
Winer, JA
中科院分区：
文献类型：
--
作者：
Lee, CC;Imaizumi, K;Winer, JA
从生理学和解剖学的角度研究了听觉皮层等效频率范围多重表征的基础。我们的目标是追踪猫的丘脑、互交和皮质信息在两个音调异位场（初级听觉皮层（AI）和前听觉场（AAF））上的收敛。这两个领域都属于大脑皮层处理的初级阶段。在特征频率的神经生理作图后，我们在AI和AAF的不同频率匹配的位点注射不同的逆行示踪剂。我们发现他们在预测上的差异，支持了听觉丘脑和大脑皮层中大量分离的并行处理流的概念。在每个领域，同侧皮质输入大约占到投射到同频域的细胞数量的70%，而共同和丘脑来源各占15%。标记的丘脑和皮质神经元集中在色散预测区域和远离其光谱预测位置的较小位点上。少数双标记的丘脑神经元(
The basis for multiple representations of equivalent frequency ranges in auditory cortex was studied with physiological and anatomical methods. Our goal was to trace the convergence of thalamic, commissural, and corticocortical information upon two tonotopic fields in the cat, the primary auditory cortex (AI) and the anterior auditory field (AAF). Both fields are among the first cortical levels of processing. After neurophysiological mapping of characteristic frequency, we injected different retrograde tracers at separate, frequency-matched loci in AI and AAF. We found differences in their projections that support the notion of largely segregated parallel processing streams in the auditory thalamus and cerebral cortex. In each field, ipsilateral cortical input amounts to similar to70% of the number of cells projecting to an isofrequency domain, while commissural and thalamic sources are each similar to15%. Labeled thalamic and cortical neurons were concentrated in tonotopically predicted regions and in smaller loci far from their spectrally predicted positions. The few double-labeled thalamic neurons (