Maternal diet quality during pregnancy and child cognition and behavior in a US cohort.
Maternal diet quality during pregnancy and child cognition and behavior in a US cohort.
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DOI：
10.1093/ajcn/nqab325
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发表时间：
2022-01-11
期刊：
影响因子：
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通讯作者：
Jacques PF
中科院分区：
文献类型：
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作者：
Mahmassani HA;Switkowski KM;Scott TM;Johnson EJ;Rifas-Shiman SL;Oken E;Jacques PF
母亲在怀孕期间摄入的几种营养素与后代的认知能力有关。母亲饮食模式与后代认知之间的关系尚不明确。我们的目的是研究怀孕期间母亲饮食质量与儿童认知和行为的关系。在前瞻性产前队列项目Viva的1580对母子中，我们使用FFQs评估孕妇孕期饮食，并使用地中海饮食评分（MDS-P）和替代健康饮食指数（AHEI-P）评估孕妇饮食质量。儿童的认知和行为结果在婴儿期和儿童早期和中期使用标准化测试和问卷进行评估。我们进行了多变量线性回归分析。母亲主要是白人，受过大学教育，不吸烟。在调整了儿童年龄、性别和母亲的社会人口统计学和生活方式特征后，怀孕期间母亲的MDS-P高（6-9）与低（0-3）相比，儿童的考夫曼简短智力测验（KBIT-II）非语言（妊娠早期平均差异：4.54;95% CI: 1.53, 7.56）和语言得分（3.78;95% CI: 1.37, 6.19）较高，执行功能行为评定量表（Brief）元认知指数(- 1.76；95% CI:−3.25,−0.27)，表明儿童中期智力较好，元认知问题较少。与怀孕期间Q1 AHEI-P相比，母亲Q4与儿童早期更高的宽范围视觉运动能力匹配评分（妊娠早期的平均差异：2.79;95% CI: 0.55, 5.04）和更高的KBIT-II语言评分（2.59;95% CI: 0.13, 5.04）和儿童中期较低的BRIEF全球执行综合评分（- 1.61;95% CI: - 3.20, - 0.01）相关，表明更好的视觉空间技能，语言智力和执行功能。母亲在怀孕期间摄入高质量的饮食与孩子在童年早期更好的视觉空间技能和孩子在童年中期更好的智力和执行功能有关。
Maternal intake of several nutrients during pregnancy is linked to offspring cognition. The relation between maternal dietary patterns and offspring cognition is less established. We aimed to examine associations of maternal diet quality during pregnancy with child cognition and behavior. Among 1580 mother–child pairs in Project Viva, a prospective prebirth cohort, we assessed maternal diet during pregnancy using FFQs and evaluated diet quality using versions modified for pregnancy of the Mediterranean Diet Score (MDS-P) and Alternate Healthy Eating Index (AHEI-P). Child cognitive and behavioral outcomes were assessed using standardized tests and questionnaires at infancy and in early and mid-childhood. We conducted multivariable linear regression analyses. Mothers were predominantly white, college-educated, and nonsmokers. After adjustment for child age and sex and maternal sociodemographic and lifestyle characteristics, maternal high (6–9) compared with low (0–3) MDS-P during pregnancy was associated with higher child Kaufman Brief Intelligence Test (KBIT-II) nonverbal (mean difference for first trimester: 4.54; 95% CI: 1.53, 7.56) and verbal scores (3.78; 95% CI: 1.37, 6.19) and lower Behavioral Rating Inventory of Executive Function (BRIEF) Metacognition Index (−1.76; 95% CI: −3.25, −0.27), indicating better intelligence and fewer metacognition problems in mid-childhood. Maternal Q4 compared with Q1 AHEI-P during pregnancy was associated with higher Wide Range Assessment of Visual Motor Abilities matching scores in early childhood (mean difference for first trimester: 2.79; 95% CI: 0.55, 5.04) and higher KBIT-II verbal scores (2.59; 95% CI: 0.13, 5.04) and lower BRIEF Global Executive Composite scores in mid-childhood (−1.61; 95% CI: −3.20, −0.01), indicating better visual spatial skills, verbal intelligence, and executive function. Maternal intake of a better-quality diet during pregnancy was associated with better visual spatial skills in the offspring at early childhood and with better intelligence and executive function in the offspring at mid-childhood.