Nanomedicines for overcoming biological barriers
Nanomedicines for overcoming biological barriers
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DOI：
10.1016/j.biopha.2004.01.007
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发表时间：
2004-04-01
影响因子：
7.5
通讯作者：
Alonso, MJ
中科院分区：
文献类型：
--
作者：
Alonso, MJ
药物给药是一个跨学科的研究领域，旨在使复杂新药的管理可行，并为目前市场上的药物增加关键价值。目前，在给药方面最吸引人的研究领域之一是设计由纳米系统组成的纳米药物，这些纳米系统能够在适当的时间将药物递送到正确的地方。本文的目的是回顾我们在开发和表征纳米系统方面取得的进展，这些纳米系统将被用作粘膜给药的药物载体。这些纳米载体能够保护相关药物免受降解，并促进其通过关键和特定屏障的运输。它们中的一些还能够以可控的方式将相关药物释放到靶组织中。这些纳米载体是由安全材料制成的，包括合成的可生物降解聚合物、脂质和多糖。许多纳米技术已经被开发出来，使各种药物与这些纳米载体相关联，从经典的小药物到大的DNA片段。体外细胞培养研究和体内实验证明了这些纳米载体在克服肠、鼻、眼等重要粘膜屏障方面的潜力。希望这将很快成为一种制造更便宜、更快、更有效药物的策略。(C) 2004年由Elsevier SAS出版。
Drug delivery is an interdisciplinary area of research that aims at making the administration of complex new drugs feasible, as well as adding critical value to the drugs that are currently in the market. At present, one of the most attractive areas of research in drug delivery is the design of nanomedicines consisting of nanosystems that are able to deliver drugs to the right place, at appropriate times. The goal of the present article is to review the advances we have made in the development and characterization of nanosystems intended to be used as drug carriers for mucosal administration. These nanocarriers are able to protect the associated drug against degradation and facilitate its transport across critical and specific barriers. Some of them, are further able to release the associated drug to the target tissue in a controlled manner. These nanocarriers have been made of safe materials, including synthetic biodegradable polymers, lipids and polysaccharides. A number of nanotechnologies have been developed that enable the association of a variety of drugs to these nanocarriers, ranging from classical small drug to large DNA fragments. The in vitro cell culture studies and the in vivo experiments have evidenced the potential of these nanocarriers for overcoming important mucosal barriers, such as the intestinal, nasal and ocular barriers. Hopefully, this will soon represent a strategy for making cheaper and faster, more efficacious medicines. (C) 2004 Published by Elsevier SAS.