Prognostic impact of semantic MRI features on survival outcomes in molecularly subtyped medulloblastoma
Prognostic impact of semantic MRI features on survival outcomes in molecularly subtyped medulloblastoma
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DOI：
10.1007/s00066-021-01889-9
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发表时间：
2022-01-21
影响因子：
3.1
通讯作者：
Jalali, Rakesh
中科院分区：
文献类型：
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作者：
Dasgupta, Archya;Gupta, Tejpal;Jalali, Rakesh
目的影像学特征反映了包括脑肿瘤在内的各种癌症的固有疾病生物学。我们报告了磁共振成像（MRI）特征对2007年至2018年在我们研究所治疗的髓母细胞瘤患者生存的预后影响。方法通过共识提取对比前和对比后t1加权和t2加权MRI的16个语义成像特征（预定义分类）。采用单因素分析和多因素Cox回归分析评估语义特征与无复发生存期（RFS）和总生存期（OS）的相关性。结果研究队列包括171例髓母细胞瘤患者（中位年龄9岁），接受最大安全切除，然后进行风险分层辅助放化疗。共有55例患者出现复发/进展性疾病（通常为神经轴转移），导致44例死亡，包括1例治疗相关死亡。在中位随访45个月（四分位数间19-65个月）时，5年Kaplan-Meier估计的RFS和OS分别为64%和71%。语义MRI特征，如肿瘤在垂直轴上的非中心位置，没有脑干受累，
Purpose Imaging features are known to reflect inherent disease biology in various cancers including brain tumors. We report on the prognostic impact of magnetic resonance imaging (MRI) features on survival in patients with medulloblastoma treated between 2007 and 2018 at our institute. Methods Sixteen semantic imaging features (with predefined categories) were extracted from pre- and postcontrast T1-weighted and T2-weighted MRI by consensus. Univariate analysis and multivariate Cox regression analysis were performed to assess the correlation of semantic features with relapse-free survival (RFS) and overall survival (OS). Results The study cohort comprised 171 medulloblastoma patients (median age 9 years) treated with maximal safe resection followed by risk-stratified adjuvant radio(chemo)therapy. A total of 55 patients experienced recurrent/progressive disease (commonly neuraxial metastases) resulting in 44 deaths, including one treatment-related death. At a median follow-up of 45 months (interquartile range 19-65 months), 5-year Kaplan-Meier estimates of RFS and OS were 64% and 71%, respectively. Semantic MRI features such as non-central tumor location on vertical axis, absence of brainstem involvement,