Transient mechanical benefits of a deep inflation in the injured mouse lung
Transient mechanical benefits of a deep inflation in the injured mouse lung
复制标题
DOI：
10.1152/japplphysiol.00473.2002
复制
发表时间：
2002-11-01
影响因子：
3.3
通讯作者：
Bates, JHT
中科院分区：
文献类型：
--
作者：
Allen, G;Lundblad, LKA;Bates, JHT
肺复张术（RM）在损伤肺中的持久作用尚未得到很好的表征。我们推测，深充气（DI）后呼吸弹性（H）的降低本质上是短暂的，在较高的呼气末正压（PEEP）下应持续更长时间。13只通气小鼠在生理盐水灌洗前后给予不同PEEP水平的2种DI。强迫振荡用于在DI后7分钟内定期测量H。估计DI后H恢复的时间常数（tau）。在所有PEEP水平下，灌洗前（80-115 s）的tau值在灌洗后（13-30 s）降低（P = 0.0001）。PEEP在灌洗前后对tau蛋白无显著影响。PEEP和灌洗对DI后H的平台水平和总恢复有显著影响（P < 0.0001）。我们的研究结果表明，对于DI在受伤的小鼠肺中是有益的，它可能必须每分钟应用几次。
The lasting effects of a recruitment maneuver (RM) in the injured lung are not well characterized. We speculated that the reduction in respiratory elastance (H) after a deep inflation (DI) is transient in nature and should be sustained longer at higher positive end-expiratory pressure (PEEP). Thirteen ventilated mice were given 2 DIs at various levels of PEEP before and after saline lavage. Forced oscillations were used to measure H periodically over 7 min after the DIs. Time constants (tau) were estimated for the post-DI recovery in H. Values for tau before lavage (80-115 s) were reduced after lavage (13-30 s) at all levels of PEEP (P = 0.0001). PEEP did not significantly influence tau before or after lavage. The plateau level and total recovery in H after a DI were significantly influenced by PEEP and lavage (P < 0.0001). Our results suggest that for a DI to be beneficial in the injured mouse lung, it may have to be applied several times a minute.