Frizzled9 protein is regionally expressed in the developing medial cortical wall and the cells derived from this region
Frizzled9 protein is regionally expressed in the developing medial cortical wall and the cells derived from this region
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DOI：
10.1016/j.devbrainres.2005.02.018
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发表时间：
2005-06-09
期刊：
影响因子：
--
通讯作者：
Pleasure, SJ
中科院分区：
文献类型：
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作者：
Zhao, CJ;Pleasure, SJ
我们使用新生成的针对 Writ 受体 Frizzled9 的特异性抗血清来检查该蛋白质在端脑中的分布。先前的研究表明，在皮质发育过程中，Frizzled9 mRNA 的表达呈从内侧高到外侧低的梯度6。我们对Frizzled9 抗血清的研究支持了妊娠中期小鼠胚胎期间的这种定位。在妊娠后期，Frizzled9 的表达在内侧皮质神经上皮的所有细胞衍生物中持续存在。从出生到成年，Frizzled9 持续在海马体的主要神经元细胞中表达。有趣的是，Frizzled9 也在成体齿状回中的星形胶质细胞和分裂神经元前体细胞中表达。因此，Frizzled9表达标记是整个啮齿类动物一生中内侧衍生的皮质衍生物的区域标记，并且将是皮质区域化调节研究中的有用标记。 (c) 2005 Elsevier B.V. 保留所有权利。
We used a newly generated antiserum specific for the Writ receptor Frizzled9 to examine the distribution of this protein in the telencephalon. Previous studies showed expression of the mRNA for Frizzled9 in a medial high to lateral low gradient during cortical development 6. Our studies with the Frizzled9 antiserum supported this localization during mid-gestation mouse embryos. Later in gestation, the expression of Frizzled9 persisted in all cellular derivatives of the medial cortical neuroepithelium. From birth through adulthood, Frizzled9 continues to be expressed in the principal neuronal cells of the hippocampus. Interestingly, Frizzled9 was also expressed by astrocytic cells and dividing neuronal precursors in the adult dentate gyrus. Thus, Frizzled9 expression marks are a regional marker of medially derived cortical derivatives throughout rodent life and will be a useful marker in the study of regulation of cortical arealization. (c) 2005 Elsevier B.V. All rights reserved.