Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition
Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition
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DOI：
10.1016/s0300-9084(02)01460-8
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发表时间：
2002-09-01
期刊：
影响因子：
3.9
通讯作者：
Hermann, T
中科院分区：
文献类型：
--
作者：
Hermann, T
本文讨论了小分子配体识别RNA靶分子的静态结构和构象柔性的作用，重点讨论了天然氨基糖苷类抗生素及其在RNA靶分子结合中的混杂性。简要概述了以前的努力，设计简化的氨基糖苷类衍生物针对细菌的解码位点RNA。(C)2002法国生物化学与生物分子学会/科学与医学版Elsevier SAS。All rights reserved.
The role of static structure and conformational flexibility in the recognition of RNA targets by small molecule ligands is discussed with emphasis on the natural aminoglycoside antibiotics and their promiscuity in RNA target binding. A brief overview is given of previous efforts to design simplified aminoglycoside derivatives targeted at the bacterial decoding site RNA. (C) 2002 Societe francaise de biochimie et biologie moleculaire/Editions scientifiques et medicales Elsevier SAS. All rights reserved.