Health implications of high dietary omega-6 polyunsaturated Fatty acids.
Health implications of high dietary omega-6 polyunsaturated Fatty acids.
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DOI：
10.1155/2012/539426
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发表时间：
2012
影响因子：
2.2
通讯作者：
Stanton C
中科院分区：
文献类型：
--
作者：
Patterson E;Wall R;Fitzgerald GF;Ross RP;Stanton C
ω-6（n-6）多不饱和脂肪酸（PUFA）（例如，花生四烯酸（AA））和ω-3（n-3）PUFA（例如，二十碳五烯酸（EPA））是称为“类二十烷酸”的有效脂质介质信号分子的前体，其在炎症调节中具有重要作用。通常，衍生自n-6 PUFA的类二十烷酸是促炎性的，而衍生自n-3 PUFA的类二十烷酸是抗炎性的。在过去几十年中，n-6和n-3 PUFA摄入量的饮食变化显示（n-6）与（n-3）的比例（~15：1）显著增加，这与n-6 PUFA的代谢比n-3 PUFA更大有关。与（n-6）：（n-3）PUFA比率的这种增加相一致的是慢性炎性疾病如非酒精性脂肪肝病（NAFLD）、心血管疾病、肥胖症、炎性肠病（IBD）、类风湿性关节炎和阿尔茨海默病（AD）的增加。通过增加西方饮食中（n-3）：（n-6）PUFA的比例，可以降低这些慢性炎症性疾病的发病率。
Omega-6 (n-6) polyunsaturated fatty acids (PUFA) (e.g., arachidonic acid (AA)) and omega-3 (n-3) PUFA (e.g., eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator signalling molecules, termed “eicosanoids,” which have important roles in the regulation of inflammation. In general, eicosanoids derived from n-6 PUFA are proinflammatory while eicosanoids derived from n-3 PUFA are anti-inflammatory. Dietary changes over the past few decades in the intake of n-6 and n-3 PUFA show striking increases in the (n-6) to (n-3) ratio (~15 : 1), which are associated with greater metabolism of the n-6 PUFA compared with n-3 PUFA. Coinciding with this increase in the ratio of (n-6) : (n-3) PUFA are increases in chronic inflammatory diseases such as nonalcoholic fatty liver disease (NAFLD), cardiovascular disease, obesity, inflammatory bowel disease (IBD), rheumatoid arthritis, and Alzheimer's disease (AD). By increasing the ratio of (n-3) : (n-6) PUFA in the Western diet, reductions may be achieved in the incidence of these chronic inflammatory diseases.