PROTECTION AGAINST FOOT-AND-MOUTH-DISEASE BY IMMUNIZATION WITH A CHEMICALLY SYNTHESIZED PEPTIDE PREDICTED FROM THE VIRAL NUCLEOTIDE-SEQUENCE
PROTECTION AGAINST FOOT-AND-MOUTH-DISEASE BY IMMUNIZATION WITH A CHEMICALLY SYNTHESIZED PEPTIDE PREDICTED FROM THE VIRAL NUCLEOTIDE-SEQUENCE
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DOI：
10.1038/298030a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
BROWN, F
中科院分区：
文献类型：
--
作者：
BITTLE, JL;HOUGHTEN, RA;BROWN, F
化学合成了口蹄疫病毒VP1多肽2个不同区域对应的多肽，在牛、豚鼠和家兔体内产生了高水平的血清型特异性病毒中和抗体。单次接种这些肽中的一种可以保护豚鼠免受随后的毒力病毒的攻击。
Chemically synthesized peptides corresponding to 2 different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype-specific virus neutralizing antibody in cattle, guinea pigs and rabbits. A single inoculation of 1 of these peptides protected guinea pigs against subsequent challenge with the virulent virus.