Role of anti-DNA antibodies in the pathogenesis of lupus nephritis
Role of anti-DNA antibodies in the pathogenesis of lupus nephritis
复制标题
DOI：
10.1016/j.autrev.2005.10.010
复制
发表时间：
2006-07-01
影响因子：
13.6
通讯作者：
Fu, Shu Man
中科院分区：
文献类型：
--
作者：
Deshmukh, Umesh S.;Bagavant, Harini;Fu, Shu Man
尽管抗 DNA 自身抗体与狼疮性肾炎之间存在良好的关联，但很难确定抗 DNA 自身抗体反应的致病潜力。有人提出，抗DNA抗体可以通过在肾脏中作为免疫复合物沉积或通过识别肾脏中的交叉反应抗原来发挥其致病作用。文献中的几项研究表明，抗 DNA 抗体与肾脏抗原的交叉反应对其致病潜力至关重要。这就提出了一个问题：DNA 是否负责 B 细胞的激活和选择，产生交叉反应性抗 DNA 抗体。最近的研究表明，DNA 以外的抗原可以引发与 dsDNA 发生交叉反应的抗体反应。此外，我们和其他人已经证明，狼疮性肾炎可以在没有抗 DNA 抗体的情况下发生。因此，对 dsDNA 的反应性应被视为多反应性自身抗体的特征之一，而不是狼疮性肾炎发病机制的主要必要条件。 (c) 2005 Elsevier B.V. 保留所有权利。
Despite a good association between anti-DNA autoantibodies and lupus nephritis, it is difficult to determine the pathogenic potential of an anti-DNA autoantibody response. It is proposed that anti-DNA antibodies can exert their pathogenic effects through deposition as immune complexes in the kidney or through the recognition of cross-reactive antigens in the kidneys. Several studies in literature demonstrate that cross-reactivity of anti-DNA antibodies with kidney antigens is critical for their pathogenic potential. This raises the question whether DNA is responsible for the activation and selection of B cells generating cross-reactive anti-DNA antibodies. Recent studies suggest that antigens other than DNA can initiate an antibody response that is cross-reactive with dsDNA. Moreover, we and other have demonstrated that lupus nephritis can occur in the absence of anti-DNA antibodies. Thus, reactivity to dsDNA should be considered as one of the characteristic of polyreactive autoantibodies and not a primary requisite for the pathogenesis of lupus nephritis. (c) 2005 Elsevier B.V. All rights reserved.