DIRECT CONTACT BETWEEN RETICULAR FIBERS AND MIGRATORY CELLS IN THE PARACORTEX OF MOUSE LYMPH-NODES - A MORPHOLOGICAL AND QUANTITATIVE STUDY
DIRECT CONTACT BETWEEN RETICULAR FIBERS AND MIGRATORY CELLS IN THE PARACORTEX OF MOUSE LYMPH-NODES - A MORPHOLOGICAL AND QUANTITATIVE STUDY
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DOI：
10.1679/aohc.51.233
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发表时间：
1988-07-01
影响因子：
--
通讯作者：
HOSHINO, T
中科院分区：
文献类型：
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作者：
HAYAKAWA, M;KOBAYASHI, M;HOSHINO, T
对小鼠淋巴结的透射电子显微镜观察表明，副皮质中的网状纤维不仅由网状细胞包裹，有时也由交错突细胞、巨噬细胞和淋巴细胞等移行细胞包裹。大量的电子显微镜定量分析表明，在裸鼠和异种鼠中，大约90%的网状纤维表面积被包裹在网状细胞的鞘内，而其余的表面积与迁移细胞有关。裸鼠的淋巴结中含有比异种动物更多的交指细胞，大约9%的表面积被包括朗格汉斯细胞在内的交指细胞占据；在异种动物中，只有约3%的面积与交指细胞有关。在裸鼠和异种鼠中，活跃吞噬的巨噬细胞约占表面积的3%。在异种小鼠体内可观察到淋巴细胞与网状纤维之间的接触，而在淋巴结中淋巴细胞很少的裸鼠中则未见这种关系。这些结果表明，淋巴结旁皮质网状细胞和网状纤维之间的联系是灵活的，允许游走细胞的介入。
Transmission electron microscope observation of mouse lymph nodes demonstrated that reticular fibers in the paracortex were invested not only by reticular cells, but occasionally also by migratory cells such as interdigitating cells, macrophages, and lymphocytes. Quantitative analysis of electron micrographs covering wide areas revealed that about 90% of the surface area of the reticular fiber was enclosed in the sheath of reticular cells in both nude and hetero mice, whereas the rest of the surface area was associated with migratory cells. In nude mice, whose lymph nodes contain more numerous interdigitating cells than hetero animals, about 9% of the surface area was occupied by interdigitating cells including Langerhans cells; in hetero mice only about 3% was associated with the interdigitating cells. Actively phagocytizing macrophages occupied about 3% of the surface area in both nude and hetero mice. Contact between lymphocytes and reticular fibers was observed in hetero mice, whereas this relation could not be demonstrated in nude mice whose lymph nodes contain very few lymphocytes. These results suggest tht the association between reticular cells and reticular fibers in the paracortex of lymph node is flexible, allowing for the interposing of migratory cells.