Fragnostic: walking through protein structure space.
Fragnostic: walking through protein structure space.
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DOI：
10.1093/nar/gki363
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发表时间：
2005-07-01
影响因子：
14.9
通讯作者：
Godzik A
中科院分区：
文献类型：
--
作者：
Friedberg I;Godzik A
Fragnostic（）web工具实现了蛋白质结构空间的新颖而有用的视图。我们挖掘了PDB的一个非冗余子集，用于在不同SCOP折叠的蛋白质之间共享的共同片段。随后，我们制定了一个折叠间的相似性度量的基础上片段共享。折叠空间被描述为一个图，其节点是折叠，根据片段共享的程度在折叠之间绘制边。以这种方式，Fragnostic帮助发现属于不同折叠的蛋白质之间的有意义的关系，基于组成这些折叠的蛋白质中的相似片段。远距离折叠相似性信息由取自基因本体论、SCOP和CATH的注释补充。总体而言，Fragnostic是一种工具，有助于发现远亲或看似无关的蛋白质之间的结构和功能关系。
The Fragnostic () web tool implements a novel and useful view of protein structure space. We mined a non-redundant subset of the PDB for common fragments shared between proteins inhabiting different SCOP folds. Subsequently, we formulated an inter-fold similarity measure based on fragment sharing. Fold space is described as a graph whose nodes are folds between which the edges are drawn depending on the extent of fragment sharing. In this fashion, Fragnostic helps discover meaningful relationships between proteins belonging to different folds, based on sharing similar fragments in the proteins comprising those folds. Distant fold similarity information is supplemented by annotations taken from Gene Ontology, SCOP and CATH. Overall, Fragnostic is a tool which helps discover structural and functional relationships between proteins which are distantly related or seemingly unrelated.
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DOI：
10.1073/pnas.0308656100
发表时间：
2004-03-16
影响因子：
11.1
作者：
Choi, IG;Kwon, J;Kim, SH
通讯作者：
Kim, SH
影响因子：
8
作者：
Rychlewski, L;Jaroszewski, L;Godzik, A
通讯作者：
Godzik, A
影响因子：
5.7
作者：
Orengo, CA;Michie, AD;Thornton, JM
通讯作者：
Thornton, JM
影响因子：
5.6
作者：
Harrison, A;Pearl, F;Orengo, C
通讯作者：
Orengo, C