Food quality and motivation: A refined low-fat diet induces obesity and impairs performance on a progressive ratio schedule of instrumental lever pressing in rats
Food quality and motivation: A refined low-fat diet induces obesity and impairs performance on a progressive ratio schedule of instrumental lever pressing in rats
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DOI：
10.1016/j.physbeh.2014.02.025
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发表时间：
2014-04-10
影响因子：
2.9
通讯作者：
Pendergrass, David C.
中科院分区：
文献类型：
--
作者：
Blaisdell, Aaron P.;Lau, Yan Lam Matthew;Pendergrass, David C.
简介：在啮齿动物模型中，与未精制的低脂饮食相比，纯化的高脂饮食 (HFD) 喂养会导致有害的代谢和认知影响。这些影响通常归因于饮食中的高脂肪含量，而很少关注与饮食高度精制状态相关的其他机制。尽管人们已经探讨了高脂饮食对认知的影响，但人们对精制食品与未精制食品对认知的影响知之甚少。我们测试了这样的假设：相对于未精制的饮食，精制低脂饮食 (LFD) 会增加体重并对认知产生不利影响。 材料和方法：允许大鼠随意食用未精制的啮齿动物饲料（CON，实验室饮食 5001）或纯化的低脂饮食（REF，研究饮食 D12450B）6 个月，并在工具杠杆按压任务中测量体重和表现 结果：在各自饮食六个月后，REF 组的体重明显高于 CON 组。与 CON 大鼠相比，REF 大鼠在蔗糖和水强化方面的杠杆压力显着减少，并且表现出显着较低的断裂点，表明乐器演奏动机的长期降低。改变大鼠的饮食 9 天对这些措施没有影响。结论：饮食引起的肥胖。使大鼠的动机行为显着缺乏，与膳食脂肪含量无关。这对肥胖和动机之间的关联具有影响。具体而言，与肥胖共存的行为特征，例如抑郁和疲劳[1]，可能是肥胖的影响而不是原因。正如我们的研究所证明的，精制食品在一定程度上会导致肥胖，但它们也可能对其他行为和认知障碍发挥重要作用。 (C) 2014 Elsevier Inc. 保留所有权利。
Introduction: Purified high-fat diet (HFD) feeding causes deleterious metabolic and cognitive effects when compared with unrefined low-fat diets in rodent models. These effects are often attributed to the diet's high content of fat, while less attention has been paid to other mechanisms associated with the diet's highly refined state. Although the effects of HFD feeding on cognition have been explored, little is known about the impact of refined vs. unrefined food on cognition. We tested the hypothesis that a refined low-fat diet (LFD) increases body weight and adversely affects cognition relative to an unrefined diet.Materials and methods: Rats were allowed ad libitum access to unrefined rodent chow (CON, Lab Diets 5001) or a purified low-fat diet (REF, Research Diets D12450B) for 6 months, and body weight and performance on an instrumental lever pressing task were recorded.Results: After six months on their respective diets, group REF gained significantly more weight than group CON. REF rats made significantly fewer lever presses and exhibited dramatically lower breaking points than CON rats for sucrose and water reinforcement, indicating a chronic reduction of motivation for instrumental performance. Switching the rats' diet for 9 days had no effect on these measures.Conclusions: Diet-induced obesity. produces a substantial deficit in motivated behavior in rats, independent of dietary fat content. This holds implications for an association between obesity and motivation. Specifically, behavioral traits comorbid with obesity, such as depression and fatigue [1], may be effects of obesity rather than contributing causes. To the degree that refined foods contribute to obesity, as demonstrated in our study, they may play a significant contributing role to other behavioral and cognitive disorders. (C) 2014 Elsevier Inc. All rights reserved.