Acinar cell carcinoma of the pancreas - Clinical analysis of 115 patients from pancreatic cancer registry of Japan Pancreas Society
Acinar cell carcinoma of the pancreas - Clinical analysis of 115 patients from pancreatic cancer registry of Japan Pancreas Society
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DOI：
10.1097/mpa.0b013e31804bfbd3
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发表时间：
2007-07-01
期刊：
影响因子：
2.9
通讯作者：
Tanaka, Masao
中科院分区：
文献类型：
--
作者：
Kitagami, Hidehiko;Kondo, Satoshi;Tanaka, Masao
目的：胰腺腺泡细胞癌（ACC）是一种罕见的肿瘤，由于没有进行大规模的临床研究，许多方面仍不清楚。方法：本研究调查了115例在日本胰腺协会胰腺癌登记处登记的患者的临床特征、治疗和治疗结果，并对治疗计划进行了审查。虽然ACC的临床分期较晚，预后较差，但76.5%的患者可手术切除，5年生存率为43.9%。术前明确ACC的诊断是困难的，但在计划普通胰腺癌的手术时应记住这一诊断。一旦确诊，应考虑手术切除的可能性，以获得更好的预后。如果ACC不可切除或复发，化疗可能会被证明是有用的。需要建立以手术为中心的多学科治疗。
Objectives: Acinar cell carcinoma (ACC) of the pancreas is a rare tumor, and many aspects remain unclear because no large-scale clinical studies have been conducted.Methods: The present study investigated the clinical characteristics, treatment, and therapeutic outcomes of 115 patients registered in the Pancreatic Cancer Registry of the Japan Pancreas Society, and therapeutic plans were reviewed.Results: Although ACC has been associated with advanced stage and poor prognosis, this tumor was resectable in 76.5% of the patients, and the 5-year survival rate after resection was favorable, being 43.9%.Conclusions: Confirming the diagnosis of ACC preoperatively is difficult, but this diagnosis should be kept in mind while planning surgery for ordinary pancreatic cancer. Once the diagnosis has been confirmed, a possibility of surgical resection should be pursued to achieve better prognosis. If ACC is unresectable or recurrent, chemotherapy is likely to prove useful. Multidisciplinary therapy centering on the role of surgery will need to be established.