Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow.
Direct and indirect effects of IFN-α2b in malignancy treatment: not only an archer but also an arrow.
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DOI：
10.1186/s40364-022-00415-y
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发表时间：
2022-09-14
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
干扰素-α2b（IFN-α2b）是属于干扰素-α（IFN-α）家族的一种高活性细胞因子。IFN-α2b具有有益的抗病毒、抗肿瘤、抗寄生虫和免疫调节活性。在某些癌症中，IFN-α2b的直接和间接抗增殖作用通过多种途径发生，主要是JAK-STAT途径。本文就IFN-α2b的作用机制和临床试验作一综述。本文还综述了IFN-α2b功能的潜在调节剂，这些调节剂可用于缓解IFN-α2b的不良反应。IFN-α2b不仅可以增强全身免疫应答，还可以直接杀死肿瘤细胞。IFN-α2b激活的JAK-STAT通路的不同部分，如干扰素α和β受体（IFNARs）、Janus激酶（JAKs）和IFN刺激的基因因子3（ISGF 3），可能是增强IFN-α2b药理作用的潜在靶点。尽管仍有一些问题有待解决，但根据目前的证据，IFN-α2b可以抑制疾病进展并改善某些类型恶性肿瘤患者的生存率。应作出更大努力，处理潜在的不利影响和并发症。
Interferon-α2b (IFN-α2b) is a highly active cytokine that belongs to the interferon-α (IFN-α) family. IFN-α2b has beneficial antiviral, antitumour, antiparasitic and immunomodulatory activities. Direct and indirect antiproliferative effects of IFN-α2b have been found to occur via multiple pathways, mainly the JAK-STAT pathway, in certain cancers. This article reviews mechanistic studies and clinical trials on IFN-α2b. Potential regulators of the function of IFN-α2b were also reviewed, which could be utilized to relieve the poor response to IFN-α2b. IFN-α2b can function not only by enhancing the systematic immune response but also by directly killing tumour cells. Different parts of JAK-STAT pathway activated by IFN-α2b, such as interferon alpha and beta receptors (IFNARs), Janus kinases (JAKs) and IFN‐stimulated gene factor 3 (ISGF3), might serve as potential target for enhancing the pharmacological action of IFN-α2b. Despite some issues that remain to be solved, based on current evidence, IFN-α2b can inhibit disease progression and improve the survival of patients with certain types of malignant tumours. More efforts should be made to address potential adverse effects and complications.
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影响因子：
6.4
作者：
Ahmed, CMI;Johnson, DE;Sugarman, BJ
通讯作者：
Sugarman, BJ
影响因子：
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通讯作者：
Carrillo, MC
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通讯作者：
Gabrilovich DI
影响因子：
254.7
作者：
Byrd, David R.;Brierley, James D.;Gress, Donna M.
通讯作者：
Gress, Donna M.