Smart latexes for bioseparation
Smart latexes for bioseparation
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DOI：
10.1023/a:1008055211667
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Fujimoto, K
中科院分区：
文献类型：
--
作者：
Kawaguchi, H;Fujimoto, K
具有亚微米直径的单分散热敏微球用于分离和收集蛋白质和其他生物分子。热敏性赋予微球两个有价值的特征。一个是微球与蛋白质之间的亲和力随温度的可控性。吸附在微球上的蛋白质的质量和数量可以通过温度来控制。另一个特点是分散稳定性的可逆控制。通过改变温度，可以容易地回收分散体中吸附了靶蛋白的微球。
Monodisperse, thermosensitive microspheres with sub-micron diameters are used for separation and collection of proteins and other biomolecules. The thermosensitivity gives the microspheres two valuable features. One is the controllability of affinity between microsphere and protein with temperature. The quality and quantity of proteins to be adsorbed on the microspheres can be controlled with temperature. The other feature is reversible control of dispersion stability. Microspheres which have adsorbed target proteins in the dispersion can be easily recovered by changing temperature.