Mediterranean diet and brain structure in a multiethnic elderly cohort
Mediterranean diet and brain structure in a multiethnic elderly cohort
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DOI：
10.1212/wnl.0000000000002121
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发表时间：
2015-11-17
期刊：
影响因子：
9.9
通讯作者：
Scarmeas, Nikolaos
中科院分区：
文献类型：
--
作者：
Gu, Yian;Brickman, Adam M.;Scarmeas, Nikolaos
目的：以确定是否更高的坚持地中海式饮食（MeDi）与较大的MRI测量的脑体积或皮质thickness.Methods：在这个横断面研究中，高分辨率结构MRI收集了674名老年人（平均年龄80.1岁）成年人没有痴呆症谁参加了以社区为基础的，多种族的队列。通过食物频率问卷收集饮食信息。使用FreeSurfer程序从MRI扫描中获得总脑体积（TBV）、总灰质体积（TGMV）、总白色物质体积（TWMV）、平均皮质厚度（mCT）和局部体积或CT。我们使用经年龄、性别、种族、教育、体重指数、糖尿病和认知调整的回归模型，研究了Medi（评分为0-9）和个体食物组与脑体积和厚度的关联。结果：与较低的Medi依从性（0-4）相比，较高的依从性（5-9）分别与13.11（p = 0.007）、5.00（p = 0.05）和6.41（p = 0.05）毫升的TBV、TGMV和TWMV相关。较高的鱼（B = 7.06，p = 0.006）和较低的肉（B = 8.42，p = 0.002）摄入量与较大的TGMV相关。较低的肉类摄入量也与较大的TBV相关（B = 12.20，p = 0.02）。较高的鱼类摄入量与0.019 mm（p = 0.03）较大的mCT相关。扣带皮层，顶叶，颞叶，海马和CT的上额叶regions. Conclusions与饮食factors.Conclusions：在老年人中，Medi坚持与较少的脑萎缩，效果类似5年的老化。更多的鱼和更少的肉摄入量可能是促进Medi对大脑结构有益的两个关键食物元素。
Objective:To determine whether higher adherence to a Mediterranean-type diet (MeDi) is related with larger MRI-measured brain volume or cortical thickness.Methods:In this cross-sectional study, high-resolution structural MRI was collected on 674 elderly (mean age 80.1 years) adults without dementia who participated in a community-based, multiethnic cohort. Dietary information was collected via a food frequency questionnaire. Total brain volume (TBV), total gray matter volume (TGMV), total white matter volume (TWMV), mean cortical thickness (mCT), and regional volume or CT were derived from MRI scans using FreeSurfer program. We examined the association of MeDi (scored as 0-9) and individual food groups with brain volume and thickness using regression models adjusted for age, sex, ethnicity, education, body mass index, diabetes, and cognition.Results:Compared to lower MeDi adherence (0-4), higher adherence (5-9) was associated with 13.11 (p = 0.007), 5.00 (p = 0.05), and 6.41 (p = 0.05) milliliter larger TBV, TGMV, and TWMV, respectively. Higher fish (b = 7.06, p = 0.006) and lower meat (b = 8.42, p = 0.002) intakes were associated with larger TGMV. Lower meat intake was also associated with larger TBV (b = 12.20, p = 0.02). Higher fish intake was associated with 0.019 mm (p = 0.03) larger mCT. Volumes of cingulate cortex, parietal lobe, temporal lobe, and hippocampus and CT of the superior-frontal region were associated with the dietary factors.Conclusions:Among older adults, MeDi adherence was associated with less brain atrophy, with an effect similar to 5 years of aging. Higher fish and lower meat intake might be the 2 key food elements that contribute to the benefits of MeDi on brain structure.