Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression.
Polygenic risk for major depression is associated with lifetime suicide attempt in US soldiers independent of personal and parental history of major depression.
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DOI：
10.1002/ajmg.b.32868
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Ursano RJ
中科院分区：
文献类型：
--
作者：
Stein MB;Jain S;Campbell-Sills L;Ware EB;Choi KW;He F;Ge T;Gelernter J;Smoller JW;Kessler RC;Ursano RJ
自杀是一个重大的公共卫生问题。尚未确定独立于MDD个人和父母病史的常见遗传变异对MDD的贡献。计算欧洲血统的美国陆军士兵MDD的多基因风险评分（使用PRS-CS）。MDD多基因风险与终生自杀企图（SA）之间的关联在模型中进行了检验，该模型还包括MDD的父母或个人病史。模型根据年龄、性别、阶层（如适用）和反映血统的10个主要成分进行调整。在第一个队列中，6573名士兵中有417名（6.3%）报告了SA的终生病史。在一个多变量模型中，包括个人[OR=3.83，95% CI：3.09-4.75]和父母MDD病史[OR=1.43，95% CI：1.13-1.82（父母一方）和OR=1.64，95% CI：1.20-2.26（父母双方）），MDD PRS与SA显著相关（OR=1.22 [95% CI：1.10-1.36]）。在第二个队列中，4900名士兵中有204名（4.2%）报告了SA的终身病史。在包括个人[OR=3.82，95% CI：2.77-5.26]和父母MDD病史[OR=1.42，95% CI：0.996-2.03（父母一方）和OR=2.21，95% CI：1.33-3.69（父母双方）]的多变量模型中，MDD PRS继续与SA相关（p = 0.0601）（OR = 1.15 [95% CI：0.994-1.33]）。一个士兵的PRS MDD传达的信息，一生SA的可能性超出了两个预测传递容易获得的采访：个人或父母的MDD病史。结果仍有待扩展到事件SA的前瞻性预测。这些发现预示着PRS在自杀未遂风险分层中的作用。
Suicide is a major public health problem. The contribution of common genetic variants for MDD independent of personal and parental history of MDD has not been established. Polygenic risk score (using PRS-CS) for MDD was calculated for US Army soldiers of European ancestry. Associations between polygenic risk for MDD and lifetime suicide attempt (SA) were tested in models that also included parental or personal history of MDD. Models were adjusted for age, sex, tranche (where applicable) and 10 principal components reflecting ancestry. In the first cohort, 417 (6.3%) of 6573 soldiers reported a lifetime history of SA. In a multivariable model that included personal [OR=3.83, 95% CI:3.09–4.75] and parental history of MDD [OR=1.43, 95% CI:1.13–1.82 for one parent and OR=1.64, 95% CI:1.20–2.26 for both parents), MDD PRS was significantly associated with SA (OR=1.22 [95% CI:1.10–1.36]). In the second cohort, 204 (4.2%) of 4900 soldiers reported a lifetime history of SA. In a multivariable model that included personal [OR=3.82, 95% CI:2.77–5.26] and parental history of MDD [OR=1.42, 95% CI:0.996–2.03 for one parent and OR=2.21, 95% CI:1.33–3.69 for both parents) MDD PRS continued to be associated (at p = 0.0601) with SA (OR = 1.15 [95% CI:0.994–1.33]). A soldier’s PRS for MDD conveys information about likelihood of a lifetime SA beyond that conveyed by two predictors readily obtainable by interview: personal or parental history of MDD. Results remain to be extended to prospective prediction of incident SA. These findings portend a role for PRS in risk stratification for suicide attempts.
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DOI：
10.1176/appi.ajp.2020.19101025
发表时间：
2020-10-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Docherty AR;Shabalin AA;DiBlasi E;Monson E;Mullins N;Adkins DE;Bacanu SA;Bakian AV;Crowell S;Chen D;Darlington TM;Callor WB;Christensen ED;Gray D;Keeshin B;Klein M;Anderson JS;Jerominski L;Hayward C;Porteous DJ;McIntosh A;Li Q;Coon H
通讯作者：
Coon H
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
7.4
作者：
Naifeh, James A.;Nock, Matthew K.;Dempsey, Catherine L.;Georg, Matthew W.;Bartolanzo, Danielle;Ng, Tsz Hin Hinz;Aliaga, Pablo A.;Dinh, Hieu M.;Fullerton, Carol S.;Mash, Holly B. Herberman;Kao, Tzu-Cheg;Sampson, Nancy A.;Wynn, Gary H.;Zaslavsky, Alan M.;Stein, Murray B.;Kessler, Ronald C.;Ursano, Robert J.
通讯作者：
Ursano, Robert J.
DOI：
10.1002/ajmg.b.32247
发表时间：
2014-07-01
影响因子：
2.8
作者：
Mullins, Niamh;Perroud, Nader;Lewis, Cathryn M.
通讯作者：
Lewis, Cathryn M.
影响因子：
17.7
作者：
Mullins, Niamh;Bigdeli, Tim B.;Lewis, Cathryn M.
通讯作者：
Lewis, Cathryn M.