Nonimmune antibody interactions of Group A Streptococcus M and M-like proteins.
Nonimmune antibody interactions of Group A Streptococcus M and M-like proteins.
复制标题
A组链球菌M和M样蛋白的非免疫抗体相互作用。
DOI：
10.1371/journal.ppat.1009248
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发表时间：
2021-03
期刊：
影响因子：
6.7
通讯作者：
Ghosh P
中科院分区：
文献类型：
--
作者：
Mills JO;Ghosh P
M和M样蛋白是广泛存在的潜在致命细菌病原体化脓性链球菌的主要毒力因子。这些蛋白质通过将特定的人类蛋白质募集到链球菌表面来赋予对先天性和适应性免疫应答的抗性。免疫球蛋白G（IgG）和A（伊加）通过其片段可结晶（Fc）结构域的M和M样蛋白的非免疫募集被描述了近40年前，但其对毒力的影响仍未得到解决。这些相互作用已被认为是在粘膜表面和分泌物，但不是在血浆中的免疫条件下的后果，而其他证据表明，在逃避非免疫血液中的吞噬细胞杀伤的重要性。最近，通过配体诱导的M样蛋白的稳定化的Fc结合的间接作用被证明增加毒力。非免疫募集也被认为有助于由S.化脓性感染该损伤可通过靶向Fc结合来治疗。这种和其他潜在的治疗应用需要重新关注M和M样蛋白的Fc结合。
M and M-like proteins are major virulence factors of the widespread and potentially deadly bacterial pathogen Streptococcus pyogenes. These proteins confer resistance against innate and adaptive immune responses by recruiting specific human proteins to the streptococcal surface. Nonimmune recruitment of immunoglobulins G (IgG) and A (IgA) through their fragment crystallizable (Fc) domains by M and M-like proteins was described almost 40 years ago, but its impact on virulence remains unresolved. These interactions have been suggested to be consequential under immune conditions at mucosal surfaces and in secretions but not in plasma, while other evidence suggests importance in evading phagocytic killing in nonimmune blood. Recently, an indirect effect of Fc-binding through ligand-induced stabilization of an M-like protein was shown to increase virulence. Nonimmune recruitment has also been seen to contribute to tissue damage in animal models of autoimmune diseases triggered by S. pyogenes infection. The damage was treatable by targeting Fc-binding. This and other potential therapeutic applications warrant renewed attention to Fc-binding by M and M-like proteins.
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