Preparation and characterization of a prolonged and sustained drug delivery system: Linear polyacrylamide in poly(N‐isopropylacrylamide)/clay hydrogels
Preparation and characterization of a prolonged and sustained drug delivery system: Linear polyacrylamide in poly(N‐isopropylacrylamide)/clay hydrogels
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DOI：
10.1002/app.35542
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发表时间：
2012-07
影响因子：
3
通讯作者：
Yongmei Jiang;Biao Li;Xiaojin Chen;Meifang Zhu
中科院分区：
文献类型：
--
作者：
Yongmei Jiang;Biao Li;Xiaojin Chen;Meifang Zhu
本文以聚N-异丙基丙烯酰胺(PNIPAAm)、粘土和线型聚丙烯酰胺(PAAM)为基础，开发了一种新型的智能给药系统，用于药物的长期和持续控制释放。在PNIPAAm/粘土水凝胶中加入不同量的线型PAAM。用扫描电子显微镜、差示扫描量热仪和压缩测量对所得水凝胶进行了表征，以研究其形态、热和机械性能。还研究了溶胀比和加热或冷却时的响应动力学，以了解SMART性能。最后，将牛血清白蛋白(BSA)作为模型药物加载到水凝胶中，考察和比较了不同温度(20℃和37℃)下的控释效果。结果表明，PNIPAAm/粘土/线型PAAM凝胶均表现出良好的智能性能，具有较高的溶胀比和较复杂的溶胀行为。尽管将线型PAAm引入PNIPAAm/粘土网络后，水凝胶的压缩性能有所下降，但仍表现出较高的压缩应力和良好的可逆性。BSA在20℃和37℃下的释放行为表明，BSA具有对外界温度变化的自动调节功能，具有较长的释放时间。©2011 Wiley期刊，Inc.J Appl Polym Sci，2012
In this contribution, a novel smart drug delivery system based on poly(N-isopropylacrylamide) (PNIPAAm), clay, and linear polyacrylamide (PAAm) was developed for prolonged and sustained controlled drug release. Various amounts linear PAAm were incorporated into PNIPAAm/clay hydrogels. Resulting hydrogels were characterized by scanning electron microscopy, differential scanning calorimetry, and compression measurements to investigate the morphological, thermal, and mechanical properties. The swelling ratio and response kinetics on heating or cooling were also investigated to understand the smart properties. Finally, bovine serum albumin (BSA), used as the model drug, was loaded into the hydrogels to examine and compare the effects of controlled release at different temperatures (20°C and 37°C). The result indicated that all the PNIPAAm/clay/linear PAAm gels showed good smart property with a higher swelling ratio and more complicated deswelling behavior. Although the compression properties of the resulting hydrogels decreased by incorporating the linear PAAm into the network of PNIPAAm/clay, they still showed high compression stress and excellent reversibility. BSA release behavior at 20°C and 37°C revealed that a prolonged release of BSA with the auto-adjustable function to external temperature changes. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012