Invasive bacterial infections of children in a rural province in the central Philippines
Invasive bacterial infections of children in a rural province in the central Philippines
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DOI：
10.4269/ajtmh.2000.62.341
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发表时间：
2000-03-01
影响因子：
3.3
通讯作者：
Ruutu, P
中科院分区：
文献类型：
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作者：
Lupisan, SP;Herva, E;Ruutu, P
在956名五岁以下的菲律宾儿童中研究了侵袭性细菌感染的病原学，这些儿童符合世界卫生组织的严重或非常严重的肺炎标准或疑似脑膜炎或败血症。最常见的侵袭性感染是肺炎链球菌（12例[1.3%]）和流感嗜血杆菌（12例[1.3%]），包括4例肺炎球菌脑膜炎和2例H。流感性脑膜炎1型是最常见的肺炎球菌血清型（12个分离株中的6个）。血清型/组1、6、14和23占侵袭性分离株的91.7%。大多数的H.血液（10/10）和脑脊液（6/7）中的流感菌株为B型。几乎所有的入侵S. pneumoniae（9/12）和H.在1岁之前发现流感病毒感染（12例中有11例），这强调需要调查儿童对H、流感B型和S的早期免疫接种。肺炎，以及母体免疫，以最大限度地发挥免疫预防的潜力。
The etiology of invasive bacterial infections was studied among 956 Filipino children less than five years old who fulfilled the World Health Organization criteria for severe or very severe pneumonia or had suspected meningitis or sepsis. The most common invasive infections were due to Streptococcus pneumoniae (12 [1.3%]) and Haemophilus influenzae (12 [1.3%]); including four cases of pneumococcal meningitis and II cases of H. influenzae meningitis. Type 1 was the most common (six of the 12 isolates) of the pneumococcal serotypes. Serotypes/groups 1, 6, 14, and 23 accounted for 91.7% of the invasive isolates. The majority of the H. influenzae strains from blood (10 out of 10) and cerebrospinal fluid (6 out of 7) were type b. Almost all of the invasive S. pneumoniae (9 out of 12) and H. influenzae (11 out of 12) infections were seen before one year of age, which stresses the need to investigate early immunization of children for H, influenzae type b and S. pneumoniae, as well as maternal immunization to maximize the potential of immunoprophylaxis.