Anti-conflict efficacy of buspirone following acute versus chronic treatment.
Anti-conflict efficacy of buspirone following acute versus chronic treatment.
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急性与慢性治疗后丁螺环酮的抗冲突功效。
DOI：
10.1007/bf00445572
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发表时间：
1989
影响因子：
3.4
通讯作者：
Commissaris,RL
中科院分区：
文献类型：
--
作者：
Schefke,DM;Fontana,DJ;Commissaris,RL
在许多动物研究中，用新型抗焦虑剂丁螺环酮进行急性治疗仅表现出最小的“抗焦虑功效”（即，与苯二氮卓类和巴比妥类药物相比，本研究检查了接受慢性试验后丁螺环酮或生理盐水治疗的受试者中丁螺环酮急性试验前激发的影响。丁螺环酮慢性试验后治疗（4 mg/kg/天，持续4周，随后8 mg/kg/天，持续12周）对CSD行为无显著影响。与先前的报告一致，在CSD范例中，对接受慢性试验后盐水治疗的受试者进行丁螺环酮（0.125-2 mg/kg，IP）的急性试验前给药仅导致适度的抗冲突作用（相对于对照约10次电击）。相比之下，长期用丁螺环酮治疗的受试者在用丁螺环酮急性激发后表现出显著更大的抗冲突作用（超过对照组多达40次电击）。这些数据与丁螺环酮的完全抗焦虑疗效需要重复给药的假设一致。
In many animal studies, acute treatment with the novel anxiolytic agent buspirone exhibits only minimal “anxiolytic efficacy” (i.e., increases in punished responding) when compared to benzodiazepines and barbiturates. The present studies examined the effects of acute pre-test challenges with buspirone in subjects receiving chronic post-test buspirone or saline treatments. Chronic post-test treatment with buspirone (4 mg/kg/day for 4 weeks, followed by 8 mg/kg/day for 12 weeks) did not significantly affect CSD behavior. Consistent with previous reports, acute pre-test administration of buspirone (0.125–2 mg/kg, IP) to subjects receiving chronic post-test saline treatment resulted in only a modest anti-conflict effect in the CSD paradigm (approximately ten shocks over control). In contrast, subjects chronically treated with buspirone exhibited a dramatically greater anti-conflict effect following acute challenge with buspirone (up to 40 shocks over control). These data are consistent with the hypothesis that the full anxiolytic efficacy of buspirone requires repeated administration.