The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer.
The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer.
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JMJD 家族组蛋白去甲基化酶在炎症和癌症之间的串扰
DOI：
10.3389/fimmu.2022.881396
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
炎症已成为调节癌症发生、进展和治疗的关键角色，它是一把双刃剑，既可以促进癌症进展和治疗耐药性，也可以诱导抗肿瘤免疫反应。越来越多的证据表明，组蛋白的表观遗传修饰与炎症和癌症有关，基于组蛋白修饰的策略已显示出治疗癌症的良好潜力。jumonji C结构域（JMJD）家族组蛋白去甲基化酶在炎症过程和癌症发展中表现出多种调节功能，许多靶向JMJD组蛋白去甲基化酶调节炎症细胞及其产物的治疗策略已在临床或临床前肿瘤模型中成功评估。本文综述了目前对JMJD组蛋白去甲基化酶在炎症和癌症之间相互作用的功能作用和机制的理解，并重点介绍了利用JMJD组蛋白去甲基化酶调节癌症相关炎症以用于未来癌症治疗的最新临床和临床前进展。
Inflammation has emerged as a key player in regulating cancer initiation, progression, and therapeutics, acting as a double edged sword either facilitating cancer progression and therapeutic resistance or inducing anti-tumor immune responses. Accumulating evidence has linked the epigenetic modifications of histones to inflammation and cancer, and histone modifications-based strategies have shown promising therapeutic potentials against cancer. The jumonji C domain-containing (JMJD) family histone demethylases have exhibited multiple regulator functions in inflammatory processes and cancer development, and a number of therapeutic strategies targeting JMJD histone demethylases to modulate inflammatory cells and their products have been successfully evaluated in clinical or preclinical tumor models. This review summarizes current understanding of the functional roles and mechanisms of JMJD histone demethylases in crosstalk between inflammation and cancer, and highlights recent clinical and preclinical progress on harnessing the JMJD histone demethylases to regulate cancer-related inflammation for future cancer therapeutics.