A gene structure of testosterone 6β-hydroxylase (P450IIIA)
A gene structure of testosterone 6β-hydroxylase (P450IIIA)
复制标题
睾酮6β-羟化酶（P450IIIA）的基因结构
DOI：
10.1016/0006-291x(91)91949-d
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发表时间：
1991
影响因子：
3.1
通讯作者：
R. Kato
中科院分区：
文献类型：
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作者：
M. Miyata;K. Nagata;Y. Yamazoe;R. Kato
大鼠睾酮6β羟基酶的基因组克隆被鉴定为P450IIIA亚家族中的第一个基因(P450 6βA)。该基因全长约25kb，由13个外显子组成，是已报道的细胞色素P-450基因中外显子数量最多的基因。外显子区域的核苷酸序列与P450PCN2和P450PCN1的核苷酸序列具有高度的相似性(Gonzalez，FJ等(1987)Mol)。牢房。比奥尔。2 969-2 974)，但在P450 6βA基因和两个cDNA之间发现了几个核苷酸的替换和缺失，表明大鼠体内存在多个P450IIIA基因。
Genomic clones of a rat testosterone 6β-hydroxylase have been isolated and characterized as the first gene (P450 6βA) among P450IIIA subfamily. This gene spans about 25Kb and consists of 13 exons, which is the largest number of exons among cytochrome P-450 genes reported previously. The nucleotide sequence of the exon region showed high similarity to those of P450PCN2 and P450PCN1 cDNA (Gonzalez, FJ et al.(1987) Mol. Cell. Biol. 2969–2974), but several replacements and deletions of nucleotide were found between the P450 6βA gene and both cDNAs, indicating the existence of multiple P450IIIA genes in rats.
影响因子：
3.6
作者：
D. Heuman;E. J. Gallagher;J. Barwick;N. Elshourbagy;P. Guzelian
通讯作者：
D. Heuman;E. J. Gallagher;J. Barwick;N. Elshourbagy;P. Guzelian
大环内酯类抗生素可抑制体内和原代单层培养物中大鼠肝细胞中糖皮质激素反应性细胞色素 P-450p 的降解。
DOI：
--
发表时间：
1986
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Watkins,PB;Wrighton,SA;Schuetz,EG;Maurel,P;Guzelian,PS
通讯作者：
Guzelian,PS