Nanocolloidal hydrogel mimics the structure and nonlinear mechanical properties of biological fibrous networks.
Nanocolloidal hydrogel mimics the structure and nonlinear mechanical properties of biological fibrous networks.
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DOI：
10.1073/pnas.2220755120
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发表时间：
2023-12
影响因子：
11.1
通讯作者：
Elisabeth Prince;S. Morozova;Zhengkun Chen;Vahid Adibnia;I. Yakavets;Sergey Vladimir Panyukov;M. Rubinst
中科院分区：
文献类型：
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作者：
Elisabeth Prince;S. Morozova;Zhengkun Chen;Vahid Adibnia;I. Yakavets;Sergey Vladimir Panyukov;M. Rubinst
组织工程学的进展受限于对人造水凝胶的依赖，这些水凝胶不能模拟生物组织的天然纳米纤维结构和机械特性。我们报道了一种仿生水凝胶，它通过重现纤维状蛋白质网络的丝状结构和独特的机械行为来应对这一挑战。该水凝胶表现出剪切硬化和压缩诱导软化，与开发的仿射模型的预测无热弯曲网络。水凝胶的非线性力学行为归因于组成细丝的力学不对称性。水凝胶组成的变化提供了一种控制其机械性能的方法。我们的研究结果表明，生物纤维凝胶的非线性力学性能可以概括在工程纤维水凝胶。
Significance Advancements in tissue engineering are limited by reliance on contrived hydrogels that fail to mimic the native nanofibrillar architecture and mechanical properties of biological tissues. We report a biomimetic hydrogel that addresses this challenge by recapitulating the filamentous structure and the unique mechanical behavior of the fibrous protein networks. The hydrogel exhibited shear-stiffening and compression-induced softening, in agreement with the predictions of the developed affine model for athermal bent network. The nonlinear mechanical behavior of the hydrogel was attributed to the mechanical asymmetry of the constituent filaments. The variation in hydrogel composition offered a way to control its mechanical properties. Our results show that the nonlinear mechanical properties of biological fibrous gels can be recapitulated in engineered fibrillar hydrogels.