Pullulan: an exopolysaccharide and its various applications.
Pullulan: an exopolysaccharide and its various applications.
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DOI：
10.1016/j.carbpol.2013.02.082
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发表时间：
2013-06
影响因子：
11.2
通讯作者：
V. Prajapati;G. K. Jani;Simin M Khanda
中科院分区：
文献类型：
--
作者：
V. Prajapati;G. K. Jani;Simin M Khanda
普鲁兰多糖是由出芽短梗霉等黑酵母发酵获得的非离子多糖，由于其独特的特性，目前在食品和制药行业中得到开发。由于其无毒、非免疫原性、非致癌性、非诱变性等特性，普鲁兰多糖正在探索各种生物医学应用，即基因递送、靶向药物治疗、组织工程、伤口愈合，并且还用于诊断应用，如灌注、受体和淋巴结目标特异性成像和血管室成像。普鲁兰多糖中α (1→4) 和α (1→6) 的独特连接赋予这种聚合物独特的物理特性，包括粘合性和形成纤维的能力。这篇综述文章介绍了普鲁兰多糖的历史概况、性质概述、生产、衍生物、其广泛的适用性以及普鲁兰多糖的最新进展。
Pullulan is a non-ionic polysaccharide obtained from fermentation of black yeast like Aureobasidium pullulans and is currently exploited in food and pharmaceutical industries due to its unique characteristics. Due to its properties like non-toxic, non-immunogenic, non-carcinogenic, non-mutagenic, pullulan is being explored for various biomedical applications viz., gene delivery, targeted drug therapy, tissue engineering, wound healing, and also being used in diagnostic applications like, perfusion, receptor, and lymph node target specific imaging and vascular compartment imaging. The unique linkage of α (1→4) and α (1→6) in pullulan endows this polymer with distinctive physical traits, including adhesive property and the ability to form fibers. This review article presents an historical outline, overview of properties, production, derivatives of pullulan, its versatile applicability and recent advances of pullulan.