Effect of Cdx2 Polymorphism on the Relationship between Dietary Calcium Intake and Peak Bone Mass in Young Japanese Women
Effect of Cdx2 Polymorphism on the Relationship between Dietary Calcium Intake and Peak Bone Mass in Young Japanese Women
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DOI：
10.3390/nu12010191
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发表时间：
2020-01-01
期刊：
影响因子：
5.9
通讯作者：
Iida, Kaoruko
中科院分区：
文献类型：
--
作者：
Oono, Fumi;Sakamoto, Yuri;Iida, Kaoruko
研究维生素D受体基因中的尾型同源异型盒蛋白2（Cdx2）多态性和钙摄入量对骨量的影响的研究显示了不一致的结果。本研究调查了钙摄入量对峰值骨量的影响是否受到日本年轻女性Cdx2多态性的影响。对500名年轻妇女进行了一项横断面研究。饮食摄入量通过食物频率问卷进行评估。骨超声评估指数（OSI），通过定性超声方法进行评估，被用作骨量指数。受试者按钙摄入量中位数分为两组。在Cdx2基因型之间和钙组之间，OSI没有差异（分别为p = 0.960，p = 0.191）。钙和Cdx2基因型之间的相互作用对OSI接近显著性（GG对GA和AA基因型，p = 0.092）。钙组之间的OSI差异在GG基因型中具有显著性（p = 0.028），但在GA或AA基因型中无显著性（分别为p = 0.501，p = 0.306）。调整协变量（体重指数和体力活动）并没有改变结果。总之，膳食钙摄入量和峰值骨量之间的关系可能会有所不同，根据Cdx2多态性。
Studies investigating the effect of the caudal-type homeobox protein 2 (Cdx2) polymorphism in the vitamin D receptor gene and calcium intake on bone mass have shown inconsistent results. This study investigated whether the effect of calcium intake on peak bone mass is affected by Cdx2 polymorphism in young Japanese women. A cross-sectional study of 500 young women was conducted. Dietary intake was assessed by the Food Frequency Questionnaire. The osteo sono-assessment index (OSI), assessed by the qualitative ultrasound method, was used as a bone mass index. The subjects were divided into two groups by the median calcium intake. The OSI was not different among Cdx2 genotypes and between calcium groups (p = 0.960, p = 0.191, respectively). The interaction between calcium and Cdx2 genotypes on the OSI approached significance (GG versus GA and AA genotypes, p = 0.092). The difference in the OSI between calcium groups was significant in the GG genotype (p = 0.028), but not in the GA or AA genotypes (p = 0.501, p = 0.306, respectively). Adjustment for covariates (body mass index and physical activity) did not change the results. In conclusion, the relationship between dietary calcium intake and peak bone mass may vary according to Cdx2 polymorphism.