Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat
Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat
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DOI：
10.1046/j.1471-4159.2003.02300.x
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发表时间：
2004-03-01
影响因子：
4.7
通讯作者：
Sarkar, DK
中科院分区：
文献类型：
--
作者：
Chen, CP;Kuhn, P;Sarkar, DK
已知某些精神疾病会改变人体的生物节律。然而，目前，关于慢性乙醇给药对生物钟或参与控制饮酒奖励和强化的-内啡肽神经元的节律的影响知之甚少。在这里，我们报告了通过液体饮食模式给予乙醇2周，消除了下丘脑弓状核中β -内啡肽神经元中促鸦片黑素皮质素mRNA表达的昼夜节律。大鼠弓形核中控制周期基因（rPeriod1 mRNA和rPeriod2 mRNA）的昼夜节律表达显著改变，表明乙醇给药扰乱了内部时钟。此外，乙醇摄入改变了视交叉上核rPeriod2和rPeriod3 mRNA水平的昼夜节律，表明乙醇也影响了中央起搏器的功能。我们的研究发现了人体生物钟及其阿片能系统对长期饮酒的脆弱性。
Certain psychiatric disorders are known to alter the body's biological rhythms. However, currently, very little information is known about the effect of chronic ethanol administration on the circadian clock or the rhythm of beta-endorphin-containing neurons that participate in the control of the reward and reinforcement of alcohol drinking. Here, we report that administration of ethanol, via a liquid diet paradigm for a period of 2 weeks, abolishes the circadian rhythm of pro-opiomelanocortin mRNA expression of beta-endorphin neurons in the arcuate nucleus of the hypothalamus. The circadian expression of the clock governing rat period genes (rPeriod1 mRNA and rPeriod2 mRNA) in the arcuate nucleus was significantly altered, suggesting that ethanol administration disrupted the internal clock. Moreover, ethanol consumption altered the circadian rhythms of rPeriod2 and rPeriod3 mRNA levels in the suprachiasmatic nucleus, suggesting that ethanol also affected the function of the central pacemaker. Our findings identified the vulnerability of the body's clock machinery and its opioidergic system to chronic alcohol drinking.