Long-term effects of early parental loss due to divorce on the HPA axis
Long-term effects of early parental loss due to divorce on the HPA axis
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DOI：
10.1016/j.yhbeh.2007.01.009
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发表时间：
2007-04-01
影响因子：
3.5
通讯作者：
Klein, Ehud
中科院分区：
文献类型：
--
作者：
Bloch, Miki;Peleg, Ido;Klein, Ehud
我们调查了长期的影响，离婚和早期分离从一个父母对HPA轴的反应，在年轻的成年人没有精神病理学。参与者是44名年轻的受试者，其中22名父母在10岁之前离婚，22名对照。精神疾病的测量与简明症状量表（BSI），家庭知觉压力的二元调整量表（DAS），和父母的债券仪器（PBI）的债券。HPA轴功能的评估包括早晨皮质醇和ACTH的基线水平以及皮质醇对CRH刺激试验的反应。在整个CRH刺激过程中，离婚组的皮质醇水平始终但不显著地较低，仅在5分钟时达到统计学显著性（p < 0.03）。各组经时效应均达到趋势水平（p < 0.06）。发现精神症状与PBI评分之间存在相关性;然而，这两个参数与HPA轴活动无关。DAS评分与ACTH之间存在显著相关性。回归模型揭示了家庭压力和亲子关系对刺激ACTH水平的影响。这些初步研究结果表明，即使在没有成人精神病理学，童年分离的历史，从一个父母由于离婚可能会导致可检测的，虽然温和的，长期的HPA轴活动的改变。此外，他们认为，家庭压力和父母关系是这种影响的重要决定因素。很可能只有在创伤性分离的背景下，离婚才对儿童的HPA轴产生显著和持续的影响。(c)2007年由Elsevier Inc.出版
We investigated the long-term effects of divorce and early separation from one parent on HPA axis reactivity, in young adults without psychopathology. Participants were 44 young subjects, 22 whose parents divorced before they reached age 10, and 22 controls. Psychiatric symptomatology was measured with the Brief Symptom Inventory (BSI), family perceived stress by the Dyadic Adjustment Scale (DAS), and bonding by the Parental Bonding Instrument (PBI). Assessment of HPA axis function included baseline morning cortisol and ACTH and cortisol response to a CRH stimulation test.No baseline or stimulated group differences were observed for ACTH. Cortisol levels were consistently but insignificantly lower in the divorce group throughout the CRH stimulation reaching statistical significance only at 5 min (p < 0.03). Group by time effect reached a trend level (p < 0.06). A correlation was found between psychiatric symptomatology and PBI scores; however, both parameters did not correlate with HPA axis activity. A significant correlation was found between DAS scores and ACTH. A regression model revealed a contributing effect for both family stress and child-parent bonding to stimulated ACTH levels. These preliminary findings suggest that even in the absence of adult psychopathology, a history of childhood separation from one parent due to divorce may lead to detectable, albeit mild, long-term alterations in HPA axis activity. Furthermore, they suggest that level of stress at home and parental bonding are important determinants of this effect. It is likely that divorce has significant and sustained effects on children's HPA axis only in the context of a traumatic separation. (c) 2007 Published by Elsevier Inc.