Multiple spin‐echo spectroscopic imaging for rapid quantitative assessment of N‐acetylaspartate and lactate in acute stroke
Multiple spin‐echo spectroscopic imaging for rapid quantitative assessment of N‐acetylaspartate and lactate in acute stroke
复制标题
多重自旋回波光谱成像快速定量评估急性中风中的 N-乙酰天冬氨酸和乳酸
DOI：
--
复制
发表时间：
2004
影响因子：
3.3
通讯作者：
U. Pilatus
中科院分区：
文献类型：
--
作者：
A. Stengel;T. Neumann;O. Singer;C. Neumann‐Haefelin;F. Zanella;H. Lanfermann;U. Pilatus
通过化学位移成像监测乳酸(Lac)和N-乙酰天冬氨酸(NAA)的信号水平，可以为急性卒中的组织损伤提供额外的知识。尽管需要这种代谢信息，但光谱成像(SI)并没有被常规用于急性中风患者，主要是因为需要较长的获取时间。数据表明，应用快速多自旋回波(MSE)SI序列可以将测量时间缩短到6分钟(每个回波序列4个自旋回波，32×32个矩阵)。Lac和NAA的绝对浓度(即mmo1/L)可以用模体替换法进行定量，其纵向和横向弛豫校正项适用于多重自旋-回波序列。在这项针对10名中风患者的先导性研究中(症状出现和24小时)，MSE-SI获得的代谢物浓度增加了其他序列(例如扩散加权成像(DWI)和灌注加权成像(PWI))无法提供的有关组织生存能力的重要信息。在10名患者中，有9名患者的代谢变化超出了表观扩散系数(ADC)病变的边界，显示Lac浓度上升至18 mmoL/L，而NAA水平有时降至检测水平以下。患者之间在Lac浓度和SI-ADC错配的大小方面有很大的差异。《医学评论》52：228-238,2004。©2004 Wiley-Liss Inc.
Monitoring the signal levels of lactate (Lac) and N‐acetylaspartate (NAA) by chemical shift imaging can provide additional knowledge about tissue damage in acute stroke. Despite the need for this metabolic information, spectroscopic imaging (SI) has not been used routinely for acute stroke patients, mainly due to the long acquisition time required. The presented data demonstrate that the application of a fast multiple spin‐echo (MSE) SI sequence can reduce the measurement time to 6 min (four spin echoes per echo train, 32 × 32 matrix). Quantification of Lac and NAA in terms of absolute concentrations (i.e., mmol/l) can be achieved by means of the phantom replacement approach, with correction terms for the longitudinal and transversal relaxation adapted to the multiple spin‐echo sequence. In this pilot study of 10 stroke patients (symptom onset < 24 hr), metabolite concentrations obtained from MSE‐SI add important information regarding tissue viability that is not provided by other sequences (e.g., diffusion‐weighted imaging (DWI) and perfusion‐weighted imaging (PWI)). Metabolic changes extended beyond the borders of the apparent diffusion coefficient (ADC) lesion in nine of the 10 patients, showing a rise in Lac concentrations up to 18 mmol/l, while NAA levels sometimes dropped below the detection level. Considerable differences among the patients in terms of the Lac concentrations and the size of the SI‐ADC mismatch were observed. Magn Reson Med 52:228–238, 2004. © 2004 Wiley‐Liss, Inc.