Short time sequential luminescence imaging of water during irradiation by protons
Short time sequential luminescence imaging of water during irradiation by protons
复制标题
质子照射期间水的短时连续发光成像
DOI：
10.1088/1748-0221/17/12/t12001
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发表时间：
2022
影响因子：
1.3
通讯作者：
Kataoka Jun
中科院分区：
文献类型：
--
作者：
Yamamoto Seiichi;Yabe Takuya;Yogo Katsunori;Akagi Takashi;Kataoka Jun
虽然在粒子离子照射过程中的水的发光成像是一种很有前途的方法，剂量估计，它只尝试了静态图像中的时间信息不包括在内。除了射束的位置分布之外，时间信息也很重要，因为来自基于同步加速器的治疗系统的射束具有称为溢出的短脉冲形状。时间信息对于高剂量率、短时间放射治疗或所谓的FLASH放射治疗也是重要的。为了测量具有精确时间信息的粒子离子束分布，我们对质子进行了短时序贯发光成像。首先，我们测量了短时间的连续发光图像，在水幻影照射150 MeV的质子使用冷却的电荷耦合器件（CCD）相机在0.143秒的时间间隔。通过这种成像，图像显示了光束分布，但是由于成像的采样率不足，在时间强度曲线中没有精确地评估溢出的形状。然后，我们测量了0.053-s间隔的短时间序列光学图像。利用该成像，图像显示可以测量溢出形状中的光束分布，但是由于光强度不足，从图像评估的图像和深度轮廓是有噪声的。因此，我们测量了短时间的顺序发光图像在荧光素（FS）水照射150 MeV质子。由于FS水产生的发光高出10倍，我们可以获得高强度的图像，使我们能够在测量期间以0.053秒的间隔根据溢出物的形状评估时间强度曲线。还从测量图像中获得了光束的深度轮廓。有了这些结果，我们证实，时间顺序发光成像是可能的，在这种情况下，FS水的图像测量在0.053-s的间隔是最有前途的测量质子照射过程中的短时间顺序发光图像。
Although luminescence imaging of water during irradiation by particle ions is a promising method for dose estimation, it has only been tried for static images in which temporal information is not included. In addition to the positional distribution of the beam, temporal information is also important because the beams from a synchrotron-based therapy system have short pulse shapes called spills. The temporal information is also important for high dose rate, short-time radiotherapy, or so-called FLASH radiotherapy. To measure the particle ion beam distributions with precise temporal information, we conducted short time sequential luminescence imaging of protons. First, we measured short time sequential luminescence images during irradiation of a water phantom by 150-MeV protons using a cooled charge-coupled device (CCD) camera at 0.143-s intervals. With this imaging, the images showed beam distributions, but the shapes of the spill were not precisely evaluated in time intensity curves due to the insufficient sampling rate of the imaging. Then we measured short time sequential optical images with 0.053-s intervals. With this imaging, the images showed that the beam distributions in the spill shape could be measured, but the image and depth profiles evaluated from the images were noisy due to the insufficient light intensity. Consequently, we measured short time sequential luminescence images during irradiation of fluorescein (FS) water by 150-MeV protons. Since FS water produced∼ 10 times higher luminescence, we could obtain high-intensity images enabling us to evaluate the time intensity curves based on the shape of the spills during measurement with 0.053-s intervals. The depth profiles of the beam were also obtained from the measured images. With these results, we confirmed that time sequential luminescence imaging was possible and, in such cases, FS water images measured at 0.053-s intervals are most promising to measure the short time sequential luminescence images during irradiation of protons.
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