Fructose prefeeding reduces the glycemic response to a high-glycemic index, starchy food in humans
Fructose prefeeding reduces the glycemic response to a high-glycemic index, starchy food in humans
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DOI：
10.1093/jn/132.9.2601
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发表时间：
2002-09-01
影响因子：
4.2
通讯作者：
Wolf, BW
中科院分区：
文献类型：
--
作者：
Heacock, PM;Hertzler, SR;Wolf, BW
本研究的目的是确定在高血糖指数的淀粉类食物之前或同时给予小剂量果糖是否会降低餐后血糖反应。非糖尿病健康成人（n = 31;平均值± SEM：年龄26 ± 1岁;体重66.1 ± 2.6 kg;体重指数23.3 ± 0.6 kg/m2）采用随机交叉设计进行研究。处理由50 g来自单独饲喂的速溶马铃薯泥的可用碳水化合物（对照）或在马铃薯餐前60、30或0分钟饲喂的10 g果糖组成。相对于摄入马铃薯粉，在-60、-30、0、15、30、45、60、90和120分钟时分析毛细血管手指针刺血样的葡萄糖浓度。与对照组相比，餐前60和30 min喂果糖，葡萄糖曲线下的正增量面积分别减少25和27%（P < 0.01）。与先前的研究表明，立即服用少量果糖会降低对葡萄糖溶液的血糖反应相反，我们发现果糖必须在淀粉类食物之前食用，以减少餐后血糖。
The study objective was to determine whether a small dose of fructose administered before or simultaneously with a high glycemic index, starchy food decreases postprandial glycemic response. Nondiabetic healthy adults (n = 31; mean +/- SEM: age, 26 +/- 1 y; weight, 66.1 +/- 2.6 kg; body mass index, 23.3 +/- 0.6 kg/m(2)) were studied in a randomized crossover design. Treatments consisted of 50 g available carbohydrate from instant mashed potatoes fed alone (control) or with 10 g fructose fed 60, 30 or 0 min before the potato meal. Capillary finger-stick blood samples were analyzed for glucose concentration at -60, -30, 0,15, 30, 45, 60, 90 and 120 min relative to the ingestion of the potato meal. Compared with the control, the positive incremental area under the glucose curve was reduced 25 and 27% (P < 0.01) when fructose was fed either 60 or 30 min before the meal, respectively. In contrast to previous studies demonstrating that immediate administration of a small amount of fructose lowers the glycemic response to a glucose solution, we found that fructose must be consumed before a starchy food to reduce post-prandial glycemia.