DOX@Ferumoxytol-Medical Chitosan as magnetic hydrogel therapeutic system for effective magnetic hyperthermia and chemotherapy in vitro
DOX@Ferumoxytol-Medical Chitosan as magnetic hydrogel therapeutic system for effective magnetic hyperthermia and chemotherapy in vitro
复制标题
DOX@Ferumoxytol-医用壳聚糖作为磁性水凝胶治疗系统，用于有效的体外磁热疗和化疗
DOI：
10.1016/j.colsurfb.2020.110896
复制
发表时间：
2020-06-01
影响因子：
5.8
通讯作者：
Ji, Min
中科院分区：
文献类型：
--
作者：
Chen, Bo;Xing, Jing;Ji, Min
磁流体热疗由于其在交变磁场中的磁滞损耗而产生足够的热量，已成为恶性肿瘤的临床治疗方法之一。磁性纳米药物还可以作为化疗药物的载体。然而，由于高的药物需求，很少有磁性纳米载体被批准用于临床。为拓宽当前磁性纳米医学的临床应用，制备了由阿霉素、Ferumoxytol和医用壳聚糖组成的新型磁性水凝胶复合物（DOX@FMT-MC），用于热疗和化疗的协同治疗。三种材料均获得临床批准。体外热诱导实验和流变学测试表明，该复合物在交变磁场中达到高温时可成功转化为物理水凝胶。药物释放实验表明该复合物具有温度依赖性的药物缓释行为。细胞凋亡实验表明，DOX@FMT-MC复合物对结肠癌细胞的体外治疗具有32.4%的协同效应，与其他治疗组相比。在小鼠皮下异种移植肿瘤中的热诱导证明了复合物的比DOX@FMT更好的加热性能。新型水凝胶复合物与三种临床可用药物的结合有望在肿瘤协同治疗中发挥巨大潜力，推动磁性纳米医学的临床适应症开发。
Magnetic fluid hyperthermia has been one clinical treatment method in malignancy on account of the sufficient heat generation, which originates from hysteresis loss of magnetic nanomedicine in alternating magnetic field. Magnetic nanomedicine can also be employed as drug carrier for chemotherapy. Nevertheless few magnetic nanocarries has been approved in clinic, owing to the high pharmaceutical demand. For broadening the clinical application of current magnetic nanomedicine, novel magnetic hydrogel complex (DOX@FMT-MC) constituted by Doxorubicin, Ferumoxytol and Medical Chitosan was produced for hyperthermia and chemo synergistic therapy. The three materials were approved in clinic. Heat induction in vitro and rheology mesurements suggested this complex succeed in transforming into physical hydrogel when reaching hyperthermia temperature in alternating magnetic field. Drug release experiment implied the complex has the temperature-dependent slow drug release behaviour. Cell apoptosis assay presented that DOX@FMT-MC complex gave enhanced synergistic efficacy with 32.4 % on colon carcinoma cell treatment in vitro, compared to other therapeutic groups. Heat induction in mice subcutaneous xenografted tumour demonstrated the better heating performance of the complex than that of DOX@FMT. The novel hydrogel complex incorporated with three clinical available drugs promises the great potential in tumour synergistic treatment, motivating the clinical indication development of magnetic nanomedicine.