STRUCTURE OF CYCLOTHIAZOMYCIN, A UNIQUE POLYTHIAZOLE-CONTAINING PEPTIDE WITH RENIN INHIBITORY ACTIVITY .1. CHEMISTRY AND PARTIAL STRUCTURES OF CYCLOTHIAZOMYCIN
STRUCTURE OF CYCLOTHIAZOMYCIN, A UNIQUE POLYTHIAZOLE-CONTAINING PEPTIDE WITH RENIN INHIBITORY ACTIVITY .1. CHEMISTRY AND PARTIAL STRUCTURES OF CYCLOTHIAZOMYCIN
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DOI：
10.1016/0040-4039(91)80859-5
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发表时间：
1991-01-07
影响因子：
1.8
通讯作者：
SETO, H
中科院分区：
文献类型：
--
作者：
AOKI, M;OHTSUKA, T;SETO, H
环硫唑霉素是链霉菌NR0516(IC50 1.66-mU-M)产生的一种新型肾素抑制剂。根据高分辨FAB质谱仪和核磁共振波谱确定其分子式为C59H64N18O14S7(MW.1472)。通过大量的2D-核磁共振实验，确定了含有噻唑、噻唑啉、杂环生色团的5个环噻唑霉素片段。
Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp.NR0516 (IC50 1.66-mu-M). Its molecular formula was determined to be C59H64N18O14S7 (MW.1472) based on high-resolution FAB mass and NMR spectroscopy. Five fragments of cyclothiazomycin containing thiazole, thiazoline, heterocyclic chromophore were clarified by extensive 2D-NMR experiments.