DNA-Inspired Adhesive Hydrogels Based on the Biodegradable Polyphosphoesters Tackified by a Nucleobase
DNA-Inspired Adhesive Hydrogels Based on the Biodegradable Polyphosphoesters Tackified by a Nucleobase
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基于核碱基增粘的可生物降解聚磷酸酯的 DNA 启发粘合水凝胶
DOI：
10.1021/acs.biomac.9b00642
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发表时间：
2019-10-01
影响因子：
6.2
通讯作者：
Yu, Xifei
中科院分区：
文献类型：
--
作者：
Wang, Wenliang;Liu, Sanrong;Yu, Xifei
由于粘性水凝胶在从可穿戴软材料到医用密封材料等方面显示出广泛的应用前景，开发新型的粘性水凝胶受到了越来越多的关注。然而，由于粘合剂的过度粘合强度和缓慢的降解或不降解行为而导致的难以去除残留物一直是具有挑战性的。受DNA中多个互补氢键相互作用的启发，首先合成了生物启发的核碱基（A、T和U）单体并用于增粘聚磷酸酯水凝胶。嘌呤环和嘧啶官能团之间的多重氢键和疏水相互作用赋予了水凝胶优异的可控粘合性能。除此之外，已经发现这些核碱基增粘的水凝胶可以容易地剥离而不留下任何残留物，并且由于磷酸酯链的水解，可以在碱性条件下完全降解。同时，在不同pH条件下，它们也表现出不同程度的可控生物降解性。该核碱基增粘的聚磷酸酯粘合水凝胶具有良好的粘合性能、可控的生物降解性和良好的生物相容性，在伤口敷料、组织封闭剂等方面显示出巨大的潜力。
Since adhesive hydrogels showed wide applications ranging from wearable soft materials to medical sealants, more and more attention has been paid toward the exploration of novel adhesive hydrogels. However, the difficulty in removing the residue caused by the excessive adhesive strength and sluggish degradation or nondegradation behaviors of the adhesive has always been challenging. Inspired by the multiple complementary hydrogen bond interactions in DNA, the bioinspired nucleobase (A, T, and U) monomers were first synthesized and used to tackify polyphosphoester hydrogels. The multiple hydrogen bonds and hydrophobic interactions between purine rings and pyrimidine functionalities endowed the hydrogels with excellent controllable adhesive properties. Besides this, it has been found that these nucleobase-tackified hydrogels could be easily peeled off without leaving any residue and could be totally degraded under alkaline conditions due to hydrolysis of phosphoester chains. At the same time, they also exhibited controllable biodegradation to different extents under the different pH conditions. The excellent adhesive performance, controllable biodegradation, and excellent biocompatibility showed by this nucleobase-tackified polyphosphoester adhesive hydrogel demonstrated its great potential in wound dressing, as a tissue sealant, and so on.