Structural determinants of reductive terpene cyclization in iridoid biosynthesis.
Structural determinants of reductive terpene cyclization in iridoid biosynthesis.
复制标题
DOI：
10.1038/nchembio.1955
复制
发表时间：
2016-01
影响因子：
14.8
通讯作者：
O'Connor SE
中科院分区：
文献类型：
--
作者：
Kries H;Caputi L;Stevenson CEM;Kamileen MO;Sherden NH;Geu-Flores F;Lawson DM;O'Connor SE
The carbon skeleton of ecologically and pharmacologically important iridoid monoterpenes is formed in a reductive cyclization reaction unrelated to canonical terpene cyclization. Here we report the crystal structure of the recently discovered iridoid cyclase (Catharanthus roseus) bound to a mechanism-inspired inhibitor that illuminates substrate binding and catalytic function of the enzyme. Key features that distinguish iridoid synthase from its close homologue, progesterone 5β-reductase, are highlighted.
