Biocomposites composed of natural rubber latex and cartilage tissue derived from human mesenchymal stem cells
Biocomposites composed of natural rubber latex and cartilage tissue derived from human mesenchymal stem cells
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DOI：
10.1016/j.mtchem.2019.03.002
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发表时间：
2019-06
影响因子：
7.3
通讯作者：
M. Kinoshita;Y. Okamoto;M. Furuya;M. Okamoto
中科院分区：
文献类型：
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作者：
M. Kinoshita;Y. Okamoto;M. Furuya;M. Okamoto
天然胶乳(NRL)主要用于传统工业产品，但目前其目标应用正在不断扩大到组织工程领域。在这里，我们介绍了NRL纳米粒子针对人骨髓间充质干细胞(HMSCs)的软骨形成能力。软骨基因表达分析证实了NRL在hMSCs体外软骨形成过程中的有效基因表达。我们首次通过hMSC球体的形成成功地制备了软骨/NRL生物复合材料，其中NRL纳米粒子在球体中表现出机械稳定的结构和坚硬的表面结构。
Natural rubber latex (NRL) is mainly used for traditional industrial products, but currently, its target application is continuously expanding into tissue engineering. Here, we have presented the chondrogenesis ability of NRL nanoparticles against human mesenchymal stem cells (hMSCs). The effective gene expression ofin vitrochondrogenesis of hMSCs with administration of NRL was confirmed as revealed by the chondrogenic gene expression analysis. We have successfully for the first time fabricated the cartilage/NRL biocomposites via hMSC spheroid formation, where the administration of NRL nanoparticles exhibited the mechanically stable structure with hard surface structure in the spheroid.