Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer's disease
Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer's disease
复制标题
DOI：
10.1016/j.neurobiolaging.2005.07.013
复制
发表时间：
2006-09-01
影响因子：
4.2
通讯作者：
Lambert, Jean-Charles
中科院分区：
文献类型：
--
作者：
Chapuis, Julien;Tian, Jinzhou;Lambert, Jean-Charles
大量研究表明，脑血管功能障碍是阿尔茨海默病认知功能下降和神经退行性变的重要原因。越来越多的证据表明，血管内皮生长因子(VEGF)在神经元保护中发挥着关键作用，而在神经退行性疾病中，这种作用缺乏活性。血管内皮生长因子基因位于6p21.3，多项研究表明该基因与阿尔茨海默病有显著的连锁关系，而血管内皮生长因子启动子内的功能多态可能改变AD的发病风险。我们在一个法国病例对照人群中评估了这种多态对AD发病风险的潜在影响，并调查了它与AD中几个脑区(额叶、颞叶、顶叶和枕叶皮质)脑血管病变(动脉硬化、白质丢失和脑淀粉样血管病变)的严重程度的相关性。没有观察到血管内皮生长因子启动子多态与AD发病风险的关联。未发现该基因多态与AD血管病变的关系。我们的数据表明，尽管这种多态性具有功能性，但它不会增加AD的风险，也不会调节血管病变的程度。(C)2005年，爱思唯尔公司出版。
Numerous observations indicate that cerebrovascular dysfunction contributes to cognitive decline and neurodegeneration in AD. Converging evidence points to a pivotal role for vascular endothelial growth factor (VEGF) in neuronal protection, and the lack of activity of this in neurodegenerative disorders. The VEGF gene is located at 6p21.3, a site several studies have shown to have significant linkage with AD, and a functional polymorphism within the VEGF promoter may alter the risk of developing AD. We assessed the potential impact of this polymorphism on the risk of developing AD in a large French case-control population, and investigated its association with the severity of brain vascular lesions (arteriosclerosis, white matter loss and cerebral amyloid angiopathy) in several brain regions (frontal, temporal, parietal and occipital cortex) in AD.No association of the VEGF promoter polymorphism with the risk of developing AD was observed. No relationship between this polymorphism and vascular pathological changes in AD was detected. Our data indicate that although this polymorphism is functional, it does not confer greater risk for AD, nor modulate the extent of vascular pathology. (c) 2005 Published by Elsevier Inc.