Symptom-Onset-To-Balloon Time, ST-Segment Resolution and In-Hospital Mortality in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention in China: From China Acute Myocardial Infarction Registry
Symptom-Onset-To-Balloon Time, ST-Segment Resolution and In-Hospital Mortality in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention in China: From China Acute Myocardial Infarction Registry
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DOI：
10.1016/j.amjcard.2016.07.058
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发表时间：
2016-11-01
影响因子：
2.8
通讯作者：
Yang, Yuejin
中科院分区：
文献类型：
--
作者：
Song, Fei;Yu, Mengyue;Yang, Yuejin
动物和影像学研究证据支持急性心肌梗死的早期再灌注。然而，在临床试验中，在接受直接经皮冠状动脉介入治疗（pPCI）的ST段抬高型心肌梗死（STEMI）患者中，球囊扩张起始（S2 B）时间对临床结局的影响不一致。此外，中国关于缺血时间的数据很少。2013年1月至2014年9月期间，在参与中国急性心肌梗死登记研究的108家医院，共有3，877例连续STEMI患者（S2 B时间可用）接受pPCI，并被分为3个S2 B组：在多变量logistic回归分析中，将12小时S2 B时间作为死亡率的独立危险因素进行了检验（主要结局）、主要不良心脑血管事件（MACCE）和心肌灌注受损（次要结局）。中位S2 B时间为5.5（3.75 - 8.50）小时。较长的S2 B时间与较高的住院死亡率相关（12小时：4.9%; p = 0.047），ST段回落12小时与ST段回落相关
Animal and imaging study evidence favors early reperfusion for acute myocardial infarction. However, in clinical trials, the effect of symptom-onset-to-balloon (S2B) time on clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) has been inconsistent. Moreover, there are few data regarding the ischemic time in China. A total of 3,877 consecutive patients with STEMI with available S2B time undergoing pPCI from January 2013 to September 2014 at 108 hospitals that participated in the China Acute Myocardial Infarction registry were included and stratified into 3 S2B groups: 12 hours S2B time was tested in multivariate logistic regression analyses as an independent risk factor of mortality (primary outcome), major adverse cardiovascular and cerebrovascular events (MACCE), and impaired myocardial perfusion (secondary outcomes). The median S2B time was 5.5 (3.75 to 8.50) hours. Longer S2B time was associated with higher in-hospital mortality (12 hours: 4.9%; p = 0.047) and ST-segment resolution 12 hours remained associated with ST-segment resolution