Carbon Nanotube Fibers for Neural Recording and Stimulation
Carbon Nanotube Fibers for Neural Recording and Stimulation
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DOI：
10.1021/acsabm.0c00861
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发表时间：
2020-09-21
影响因子：
4.7
通讯作者：
Ma, Yishan
中科院分区：
文献类型：
--
作者：
Alvarez, Noe T.;Buschbeck, Elke;Ma, Yishan
神经元电活动的记录和刺激是神经科学中非常感兴趣的主题。许多记录技术，甚至神经系统疾病的治疗，可以受益于微电极，该微电极是柔性的，化学惰性的，导电的，并优先通过电容电荷注入转移电子。目前存在的商用电极和其他正在测试的电极，目的是促进和改善固体材料和生物组织之间的电子传输，但仍然存在一些局限性。本文讨论了碳纳米管（CNT）为基础的微电极记录和刺激神经元，并比较其电子传输能力的贵金属，如Au和Ag。以Au、Ag丝和碳纳米管纤维为电极，对大泡肉蝇（Sarcophaga bullata）进行了视网膜电图记录。通过将Au线和CNT纤维植入马达加斯加嘶嘶蟑螂（Gromphadorhina portentosa）的触角中来控制它们的运动来证明刺激。我们的研究结果表明，CNT纤维的一个特殊的属性是其高速率的电子转移，导致一个数量级较低的阻抗相比，Au和Ag和一个令人印象深刻的15.09电荷注入容量。我们还确定了这种碳纳米材料组装体在体内电生理学方面表现良好，使其成为神经生理学应用的一个有前途的前景。
Recordings and stimulations of neuronal electrical activity are topics of great interest in neuroscience. Many recording techniques, and even treatment of neurological disorders, can benefit from a microelectrode that is flexible, chemically inert, and electrically conducting and preferentially transfers electrons via capacitive charge injection. Commercial electrodes that currently exist and other electrodes that are being tested with the purpose of facilitating and improving the electron transport between solid materials and biological tissues still have some limitations. This paper discusses carbon nanotube (CNT)-based microelectrodes to record and stimulate neurons and compares their electron transport capabilities to noble metals such as Au and Ag. The recording ability of electrodes is tested through electroretinography on Sarcophaga bullata fly eyes by using Au and Ag wires and CNT fibers as electrodes. Stimulation is demonstrated through the implantation of Au wire and CNT fibers into the antennas of the Madagascar hissing cockroach (Gromphadorhina portentosa) to control their locomotion. Our results demonstrate that a particular property of the CNT fiber is its high rate of electron transfer, leading to an order of magnitude lower impedance compared to Au and Ag and an impressive 15.09 charge injection capacity. We also established that this carbon nanomaterial assembly performs well for in vivo electrophysiology, rendering it a promising prospect for neurophysiological applications.