EFFECTS OF ORAL-ADMINISTRATION OF TYPE-II COLLAGEN ON RHEUMATOID-ARTHRITIS
EFFECTS OF ORAL-ADMINISTRATION OF TYPE-II COLLAGEN ON RHEUMATOID-ARTHRITIS
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DOI：
10.1126/science.8378772
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发表时间：
1993-09-24
期刊：
影响因子：
56.9
通讯作者：
WEINER, HL
中科院分区：
文献类型：
--
作者：
TRENTHAM, DE;DYNESIUSTRENTHAM, RA;WEINER, HL
类风湿关节炎是一种炎性滑膜疾病，被认为与T细胞对关节内抗原的反应有关。II型胶原是关节软骨的主要蛋白，是本病潜在的自身抗原。口服自身抗原耐受抑制T细胞介导的自身免疫性疾病的动物模型，包括两种类风湿关节炎模型。在这项随机双盲试验中，60名患有严重活动性类风湿关节炎的患者服用了3个月的鸡II型胶原蛋白后，肿胀关节和柔软关节的数量减少，而服用安慰剂的患者则没有。胶原蛋白组有4例患者病情完全缓解。没有明显的副作用。这些数据证明了口服耐受性方法治疗类风湿性关节炎的临床疗效。
Rheumatoid arthritis is an inflammatory synovial disease thought to involve T cells reacting to an antigen within the joint. Type II collagen is the major protein in articular cartilage and is a potential autoantigen in this disease. Oral tolerization to autoantigens suppresses animal models of T cell-mediated autoimmune disease, including two models of rheumatoid arthritis. In this randomized, double-blind trial involving 60 patients with severe, active rheumatoid arthritis, a decrease in the number of swollen joints and tender joints occurred in subjects fed chicken type II collagen for 3 months but not in those that received a placebo. Four patients in the collagen group had complete remission of the disease. No side effects were evident. These data demonstrate clinical efficacy of an oral tolerization approach for rheumatoid arthritis.