High prevalence of hypogonadism determined by serum free testosterone level in Japanese testicular cancer survivors
High prevalence of hypogonadism determined by serum free testosterone level in Japanese testicular cancer survivors
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DOI：
10.1111/iju.13537
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发表时间：
2018-05-01
影响因子：
2.6
通讯作者：
Nishiyama, Hiroyuki
中科院分区：
文献类型：
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作者：
Kurobe, Masahiro;Kawai, Koji;Nishiyama, Hiroyuki
目的性腺功能减退是睾丸癌幸存者的主要并发症，但其患病率在不同研究中有所不同。在日本，游离睾酮已被用于诊断迟发性性腺功能减退综合症。在本研究中，我们评估了睾丸癌幸存者的激素水平及其对其生活质量的影响。方法共纳入1990年至2013年接受治疗的50例睾丸癌幸存者。中位年龄为44岁。测定血清游离睾酮、总睾酮和黄体生成素水平。所有患者均完成老年男性症状量表和国际勃起功能指数-15。以337名健康志愿者的激素水平为对照。结果32例（64%）患者出现游离睾酮水平
ObjectiveHypogonadism is a major complication in testicular cancer survivors, but its prevalence varies among studies. In Japan, free testosterone has been used for diagnosis of late-onset hypogonadism syndrome. In the present study, we evaluated the hormone level of testicular cancer survivors and its impact on their quality of life.MethodsOverall, 50 testicular cancer survivors treated from 1990 to 2013 were enrolled. The median age was 44 years. The serum levels of free testosterone, total testosterone and luteinizing hormone were measured. All patients completed the Aging Males' Symptom scale and International Index of Erectile Function-15. The hormone levels of 337 healthy volunteers were used as the control.ResultsA total of 32 (64%) patients showed free testosterone levels