Exploring gene expression signatures for predicting disease free survival after resection of colorectal cancer liver metastases.
Exploring gene expression signatures for predicting disease free survival after resection of colorectal cancer liver metastases.
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DOI：
10.1371/journal.pone.0049442
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Rinkes IH
中科院分区：
文献类型：
--
作者：
Snoeren N;van Hooff SR;Adam R;van Hillegersberg R;Voest EE;Guettier C;van Diest PJ;Nijkamp MW;Brok MO;van Leenen D;Koerkamp MJ;Holstege FC;Rinkes IH
这项研究旨在识别和验证可以预测因结直肠肝转移（CRLM）而接受根治性切除术的患者无病生存期（DFS）的基因特征。从Paul Brousse医院（法国）和乌得勒支大学医学中心（荷兰）接受CRLM手术的119名患者中收集肿瘤基因表达谱。将患者分为高风险组和低风险组。使用随机选择的训练集来寻找预测性基因标签。在包括剩余患者的独立验证集中测试这些基因签名预测DFS的能力。此外，在我们的完整患者队列中测试了5个已知的临床风险评分。在验证集中没有发现显著预测DFS的基因签名。相比之下，我们的患者队列中五分之三的临床风险评分能够预测DFS。在接受CRLM切除术的患者中，没有发现可以预测DFS的基因特征。在我们的患者队列中，五分之三的临床风险评分能够预测DFS。这些结果强调了在独立患者组中验证风险评分的必要性，并为未来的研究提出了改进的设计。
This study was designed to identify and validate gene signatures that can predict disease free survival (DFS) in patients undergoing a radical resection for their colorectal liver metastases (CRLM). Tumor gene expression profiles were collected from 119 patients undergoing surgery for their CRLM in the Paul Brousse Hospital (France) and the University Medical Center Utrecht (The Netherlands). Patients were divided into high and low risk groups. A randomly selected training set was used to find predictive gene signatures. The ability of these gene signatures to predict DFS was tested in an independent validation set comprising the remaining patients. Furthermore, 5 known clinical risk scores were tested in our complete patient cohort. No gene signature was found that significantly predicted DFS in the validation set. In contrast, three out of five clinical risk scores were able to predict DFS in our patient cohort. No gene signature was found that could predict DFS in patients undergoing CRLM resection. Three out of five clinical risk scores were able to predict DFS in our patient cohort. These results emphasize the need for validating risk scores in independent patient groups and suggest improved designs for future studies.
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影响因子：
3.8
作者：
Takahashi, S;Inoue, K;Kinoshita, T
通讯作者：
Kinoshita, T
影响因子：
7.7
作者：
van de Peppel, J;Kemmeren, P;Holstege, FCP
通讯作者：
Holstege, FCP
DOI：
10.1016/s0197-2456(98)00037-3
发表时间：
1998-12-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Dupont, WD;Plummer, WD
通讯作者：
Plummer, WD
影响因子：
45.3
作者：
Wang, YX;Jatkoe, T;Atkins, D
通讯作者：
Atkins, D
影响因子：
9
作者：
Fong, Y;Fortner, J;Blumgart, LH
通讯作者：
Blumgart, LH