Monitoring the Release of Silver from a Supramolecular Fullerene C60-AgNO3 Nanomaterial
Monitoring the Release of Silver from a Supramolecular Fullerene C60-AgNO3 Nanomaterial
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DOI：
10.1246/bcsj.20210028
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发表时间：
2021-04-01
影响因子：
4
通讯作者：
Shrestha, Lok Kumar
中科院分区：
文献类型：
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作者：
Hill, Jonathan P.;Shrestha, Rekha Goswami;Shrestha, Lok Kumar
研究了银从超分子富勒烯-硝酸银(I)络合物C-60 (AgNO3)(5) 中的释放。使用小分子有机超凝胶剂 1-苯基-3-(喹啉-5-基)脲监测用溶剂处理时复合物中硝酸银 (I) 的释放，该超凝胶剂选择性地与 AgNO3 相互作用，产生稳定的凝胶，其程度（即凝胶化溶剂的体积分数）和持久性表明，当长时间浸入 2-丙醇中时，Ag+ 阳离子会从复合物中持续释放。使用扫描电子显微镜评估了 AgNO3 释放对 C-60 (AgNO3)(5) 复合晶体形态的影响，结果表明 AgNO3 同时以银纳米颗粒的形式沉积在晶体-溶液界面上，沉积在不溶性 C-60 晶体框架上。还对银的释放进行了电位监测，揭示了银纳米颗粒的出现。最初强烈释放 Ag+（以 AgNO3 形式），然后将银还原固定为纳米颗粒形式，以实现长期杀菌活性。后者是通过观察水性介质中细菌菌落的活力而建立的，当介质中存在 C-60(AgNO3)(5) 晶体时，细菌菌落的生长基本上被抑制，而原始 C-60 的情况则相反，其中菌落生长不受阻碍。使用 HeLa 细胞系进行的细胞增殖研究表明，C(60)(AgNO3)(5) 晶体在水介质中也表现出抗增殖特性。
Release of silver from the supramolecular fullerene-silver(I) nitrate complex C-60 (AgNO3)(5) was investigated. Silver(I) nitrate release from the complex on treatment with solvent was monitored using the small molecule organo-supergelator 1-phenyl-3-(quinolin-5-yl)urea, which interacts selectively with AgNO3 yielding a stable gel whose extent (i.e. volume fraction of solvent gelated) and persistence indicate that Ag+ cations are continuously released from the complex when immersed in 2-propanol over extended periods of time. The effect of AgNO3 release on the morphology of the C-60 (AgNO3)(5) complex crystals was evaluated using scanning electron microscopy showing that AgNO3 is concurrently deposited as silver nanoparticles at the crystal-solution interface onto an insoluble C-60 crystalline framework. Silver release was also monitored potentiometrically revealing emergence of Ag nanoparticles. Initial intense release of Ag+ (in the form of AgNO3) is followed by reductive fixing of silver in nanoparticulate form for longer term bactericidal activity. The latter was established by observing viability of bacterial colonies in aqueous medium where their growth was essentially arrested when C-60(AgNO3)(5) crystals were present in the medium in contrast to the case for pristine C-60 where colony growth proceeded unhindered. Cell proliferation studies using HeLa cell line revealed thatC(60)(AgNO3)(5) crystals also exhibit antiproliferative properties in aqueous media.